Relevance of Dementia in Atrial Fibrillation Patients within a Specific European Health Care Area.
Neuroepidemiology
; 51(1-2): 11-18, 2018.
Article
en En
| MEDLINE
| ID: mdl-29763917
ABSTRACT
INTRODUCTION:
Atrial fibrillation might increase the risk of dementia. We aim to test the hypothesis that dementia could reclassify the actual risk of stroke and death predicted by the CHA2DS2-VASc in patients with atrial fibrillation (AF).METHODS:
A prospective study performed in a specific health care area.RESULTS:
From our health care area (n = 348,985), throughout 2013, AF was codified in 7,990 (2.08%). Mean age was 76.83 ± 10.5, mean CHA2DS2-VASc = 3.5, 4,056 (50.8%) were females and 287 (3.6%) were diagnosed to have dementia. Patients with dementia were older and presented a higher rate of all the components of the CHA2DS2-VASc-expect vasculopathy. Differences in overall mortality were observed but not in stroke and haemorrhagic events. After propensity score matched analysis, dementia was independently associated with all-cause mortality. Addition of dementia to CHA2DS2-VASc reclassified 7.7 and 16.6% of the cohort with regard to thromboembolic events and death risk respectively.CONCLUSIONS:
Patients with dementia presented a more adverse risk profile, with significant differences in all-cause mortality.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Fibrilación Atrial
/
Tromboembolia
/
Demencia
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
País/Región como asunto:
Europa
Idioma:
En
Revista:
Neuroepidemiology
Año:
2018
Tipo del documento:
Article
País de afiliación:
España