CSF1R-dependent myeloid cells are required for NKmediated control of metastasis.
JCI Insight
; 3(10)2018 05 17.
Article
en En
| MEDLINE
| ID: mdl-29769439
ABSTRACT
Myeloid leukocytes are essentially involved in both tumor progression and control. We show that neo-adjuvant treatment of mice with an inhibitor of CSF1 receptor (CSF1R), a drug that is used to deplete tumor-associated macrophages, unexpectedly promoted metastasis. CSF1R blockade indirectly diminished the number of NK cells due to a paucity of myeloid cells that provide the survival factor IL-15 to NK cells. Reduction of the number of NK cells resulted in increased seeding of metastatic tumor cells to the lungs but did not impact on progression of established metastases. Supplementation of mice treated with CSF1R-inhibitor with IL-15 restored numbers of NK cells and diminished metastasis. Our data suggest that CSF1R blockade should be combined with administration of IL-15 to reduce the risk of metastasis.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Células Asesinas Naturales
/
Receptores de Factor Estimulante de Colonias de Granulocitos y Macrófagos
/
Células Mieloides
Límite:
Animals
Idioma:
En
Revista:
JCI Insight
Año:
2018
Tipo del documento:
Article
País de afiliación:
Suiza