[Expression and significance of polymeric immunoglobulin receptor in nasal polyps].
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
; 31(1): 43-47, 2017 Jan.
Article
en Zh
| MEDLINE
| ID: mdl-29774684
ABSTRACT
Objective:
To explore the expression of polymeric immunoglobulin receptor in nasal polyps of patients with chronic rhinosinusitis with nasal polyps, and to investigateits relationship with the pathogenesis of nasal polyps.Method:
Thirty-six specimens of nasal polyps were harvested patients were selected for the control group who had operation of nasal septal construction in the corresponding time period. The pIgR and IgA expression in nasal polyps and normal nasal inferior turbinate mucosa were detected by immunohistochemistryï¼and the real-time reverse transcriptionï¼RT-PCRï¼ were used to detect the level of pIgRï¼IgAï¼RORc and Foxp3 mRNA expression in nasal polyps and normal nasal inferior turbinate mucosa. The association between pIgR mRNA and their association with the number of EOSï¼RORc mRNAï¼Foxp3 mRNA were analyzedï¼respectivelyï¼Result:
The expression of pIgR in the nasal polyps was significantly lowerer than that in control group, and the result was statistically significant(P<0.05)ï¼Compared with nasal polyps with no eosinophils, the expression levels of pIgR in the nasal polyps with eosinophils was lower\, and the result was statistically significant(P<0.05).The expression of IgA in the nasal polyps was significantly higherthan that in control , and the result was statistically significantî(P<0.05).Compared with control, the mRNA expression of pIgR and Foxp3 in the nasal polyps were significantly lowerï¼while the expression levels of IgA mRNA and Foxp3 mRNA in the nasal polyps was significantly higher compared to controls, and the result was statistically significant(P<0.05).In nasal polyps ,pIgR mRNA expression was correlated with RORc mRNA (P<0.05ï¼r=-0.79)ï¼and there was no correlation between pIgR mRNA and Foxp3 mRNAï¼P>0.05ï¼r=0.36ï¼.Conclusion:
It was proved that pIgR down-regulation play an important role in the development of nasal polypsï¼.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Sinusitis
/
Pólipos Nasales
/
Receptores de Superficie Celular
/
Receptores de Inmunoglobulina Polimérica
Límite:
Humans
Idioma:
Zh
Revista:
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
Año:
2017
Tipo del documento:
Article