[RESEARCH PROGRESS OF IN VIVO TWO-PHOTON IMAGING IN SPINAL CORD].

ABSTRACT

OBJECTIVE: To review the in vivo imaging research progress of two-photon microscopy (TPM) in spinal cord. METHODS: The recent literature concerning in vivo two-photon imaging of axon, microglia, and calcium in transgenic mice spinal cord was extensively consulted and reviewed. RESULTS: In vivo two-photon imaging of spinal cord provide dynamic information about axonal degeneration and regeneration, microglial accumulation, and calcium influx after spinal cord injury. CONCLUSIONS: TPM in vivo imaging study on spinal cord will provide theoretical foundation for pathophysiologic process of spinal cord injury.