MALAT1 via microRNA-17 regulation of insulin transcription is involved in the dysfunction of pancreatic ß-cells induced by cigarette smoke extract.

Sun, Qian; Xu, Hui; Xue, Junchao; Yang, Qianlei; Chen, Chao; Yang, Ping; Han, Aohan; Tu, Qingyun; Lu, Jiachun; Gao, Xiaohua; Xiang, Quanyong; Liu, Qizhan

Sun, Qian; Xu, Hui; Xue, Junchao; Yang, Qianlei; Chen, Chao; Yang, Ping; Han, Aohan; Tu, Qingyun; Lu, Jiachun; Gao, Xiaohua; Xiang, Quanyong; Liu, Qizhan.

Afiliación

Sun Q; Institute of Toxicology, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, China.
Xu H; The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, China.
Xue J; Institute of Toxicology, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, China.
Yang Q; The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, China.
Chen C; Institute of Toxicology, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, China.
Yang P; The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, China.
Han A; Institute of Toxicology, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, China.
Tu Q; The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, China.
Lu J; Institute of Toxicology, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, China.
Gao X; The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, China.
Xiang Q; School of Public Health, Institute for Chemical Carcinogenesis, Guangzhou Medical University, Guangzhou, Guangdong, China.
Liu Q; Institute of Chronic Non-Communicable Disease Control, Jiangsu Center for Disease Control and Prevention, Nanjing, Jiangsu, China.

J Cell Physiol ; 233(11): 8862-8873, 2018 11.

Article en En | MEDLINE | ID: mdl-29856480

Asunto(s)

Adenocarcinoma del Pulmón/genética; Proteínas Portadoras/genética; Fumar Cigarrillos/efectos adversos; MicroARNs/genética; ARN Largo no Codificante/genética; Adenocarcinoma del Pulmón/inducido químicamente; Adenocarcinoma del Pulmón/patología; Apoptosis/genética; Proteínas Portadoras/metabolismo; Transformación Celular Neoplásica/efectos de los fármacos; Transformación Celular Neoplásica/genética; Fumar Cigarrillos/epidemiología; Diabetes Mellitus/epidemiología; Diabetes Mellitus/genética; Diabetes Mellitus/patología; Regulación Neoplásica de la Expresión Génica/efectos de los fármacos; Técnicas de Silenciamiento del Gen; Hemoglobina Glucada/genética; Humanos; Insulina/genética; Resistencia a la Insulina/genética; Células Secretoras de Insulina/efectos de los fármacos; Células Secretoras de Insulina/metabolismo; Células Secretoras de Insulina/patología; ARN Largo no Codificante/metabolismo; Transducción de Señal/genética; Productos de Tabaco/toxicidad

Palabras clave

cigarette smoke extract (CSE); diabetes; metastasis-associated lung adenocarcinoma transcript 1 (MALAT1); microRNA (miR)-17; smoking

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas Portadoras / MicroARNs / ARN Largo no Codificante / Fumar Cigarrillos / Adenocarcinoma del Pulmón Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Cell Physiol Año: 2018 Tipo del documento: Article País de afiliación: China

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