In vitro effects of brominated flame retardants, selected metals and their mixtures on ethoxyresorufin-O-deethylase activity in Mossambica tilapia liver.
Ecotoxicol Environ Saf
; 161: 350-355, 2018 10.
Article
en En
| MEDLINE
| ID: mdl-29890436
ABSTRACT
The in vitro effects of individual brominated flame retardants (BFRs), selected metals, and their binary mixtures on ethoxyresorufin-O-deethylase (EROD) activity were evaluated using a plate-reader method. The BFRs, 2,2',4,4'-tetrabromodiphenyl ether (BDE-47), decabromodiphenyl oxide (BDE-209), hexabromocyclododecane (HBCD), and tetrabromobisphenol A (TBBPA), were tested at doses ranging from 0.1â¯ng/L to 100⯵g/L. Selected metals (Cu2+, Cd2+, Hg2+, and Zn2+) were screened at doses of 0.1â¯mg/L to 50â¯mg/L. The activity of EROD was significantly induced by TBBPA, BDE-209, and Zn2+, while HBCD, Cu2+, Cd2+, and Hg2+ decreased EROD activity. Moreover, following exposure to binary mixtures of metals and BFRs, the EROD activity dose-response curves were similar to those of the metals alone, indicating that EROD activity was governed by the metals.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Tilapia
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Bifenilos Polibrominados
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Metales Pesados
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Citocromo P-450 CYP1A1
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Retardadores de Llama
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Hígado
Límite:
Animals
Idioma:
En
Revista:
Ecotoxicol Environ Saf
Año:
2018
Tipo del documento:
Article
País de afiliación:
China