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In Vitro Susceptibility of Burkholderia cepacia Complex Isolated from Cystic Fibrosis Patients to Ceftazidime-Avibactam and Ceftolozane-Tazobactam.
Van Dalem, A; Herpol, M; Echahidi, F; Peeters, C; Wybo, I; De Wachter, E; Vandamme, P; Piérard, D.
Afiliación
  • Van Dalem A; Department Microbiology, National Reference Center for Burkholderia Cepacia Complex (NRC), Universitair Ziekenhuis Brussel (UZ Brussel), Vrije Universiteit Brussel (VUB), Brussels, Belgium Annelien.VanDalem@uzbrussel.be.
  • Herpol M; Department Microbiology, National Reference Center for Burkholderia Cepacia Complex (NRC), Universitair Ziekenhuis Brussel (UZ Brussel), Vrije Universiteit Brussel (VUB), Brussels, Belgium.
  • Echahidi F; Department Microbiology, National Reference Center for Burkholderia Cepacia Complex (NRC), Universitair Ziekenhuis Brussel (UZ Brussel), Vrije Universiteit Brussel (VUB), Brussels, Belgium.
  • Peeters C; Department of Biochemistry and Microbiology, National Reference Center for Burkholderia Cepacia Complex (NRC), Faculty of Sciences, Ghent University, Ghent, Belgium.
  • Wybo I; Department Microbiology, National Reference Center for Burkholderia Cepacia Complex (NRC), Universitair Ziekenhuis Brussel (UZ Brussel), Vrije Universiteit Brussel (VUB), Brussels, Belgium.
  • De Wachter E; Department Paediatrics, Cystic Fibrosis Center, Universitair Ziekenhuis Brussel (UZ Brussel), Vrije Universiteit Brussel (VUB), Brussels, Belgium.
  • Vandamme P; Department of Biochemistry and Microbiology, National Reference Center for Burkholderia Cepacia Complex (NRC), Faculty of Sciences, Ghent University, Ghent, Belgium.
  • Piérard D; Department Microbiology, National Reference Center for Burkholderia Cepacia Complex (NRC), Universitair Ziekenhuis Brussel (UZ Brussel), Vrije Universiteit Brussel (VUB), Brussels, Belgium.
Antimicrob Agents Chemother ; 62(9)2018 09.
Article en En | MEDLINE | ID: mdl-29914964
ABSTRACT
We tested the in vitro susceptibility of ceftazidime-avibactam and ceftolozane-tazobactam and 13 other antibiotics against 91 Burkholderia cepacia complex (BCC) strains isolated from cystic fibrosis patients since 2012. The highest susceptibility (82%) was found for trimethoprim-sulfamethoxazole. Eighty-one and 63% of all BCC strains were susceptible to ceftazidime-avibactam and ceftolozane-tazobactam, respectively. For temocillin, ceftazidime, piperacillin-tazobactam, and meropenem, at least 50% of the strains were susceptible. B. stabilis seems to be more resistant than other BCC species.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Ceftazidima / Cefalosporinas / Fibrosis Quística / Complejo Burkholderia cepacia / Compuestos de Azabiciclo / Tazobactam Límite: Humans Idioma: En Revista: Antimicrob Agents Chemother Año: 2018 Tipo del documento: Article País de afiliación: Bélgica
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Ceftazidima / Cefalosporinas / Fibrosis Quística / Complejo Burkholderia cepacia / Compuestos de Azabiciclo / Tazobactam Límite: Humans Idioma: En Revista: Antimicrob Agents Chemother Año: 2018 Tipo del documento: Article País de afiliación: Bélgica