ANOVA, analysis of variance; Anabolics; BMC, bone mineral content; BMP, bone morphogenetic protein; BS, bone surface; Bone; Cn, cancellous; Ct, cortical; Ec, endocortical; Ec.Pm, endocortical perimeter; LC, lining cells; LCM, laser capture micro-dissection; MS/BS, mineralizing surface; OB, osteoblast(s); OCy, osteocyte(s); OP, osteoprogenitor(s); OPG, osteoprotegerin; OVX, ovariectomized; Osteoporosis; Ps, periosteal; Ps.Pm, periosteal perimeter; RANKL, receptor activator of nuclear factor kappa-B ligand; Scl-Ab, sclerostin antibody; Scl-AbVI, 50 mg/kg of a Scl-Ab; TFP, treatment-free period; TGF, transforming growth factor; TP, treatment period; Therapeutics; VEH, vehicle; Wnt signaling; pQCT, peripheral quantitative computed tomography; s.c., subcutaneous