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Design, synthesis, X-ray studies, and biological evaluation of novel BACE1 inhibitors with bicyclic isoxazoline carboxamides as the P3 ligand.
Ghosh, Arun K; Ghosh, Koena; Brindisi, Margherita; Lendy, Emma K; Yen, Yu-Chen; Kumaragurubaran, Nagaswamy; Huang, Xiangping; Tang, Jordan; Mesecar, Andrew D.
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  • Ghosh AK; Department of Chemistry, Purdue University, West Lafayette, IN 47907, United States; Department of Medicinal Chemistry, Purdue University, West Lafayette, IN 47907, United States. Electronic address: akghosh@purdue.edu.
  • Ghosh K; Department of Chemistry, Purdue University, West Lafayette, IN 47907, United States.
  • Brindisi M; Department of Chemistry, Purdue University, West Lafayette, IN 47907, United States.
  • Lendy EK; Department of Biochemistry, Purdue University, West Lafayette, IN 47907, United States.
  • Yen YC; Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, United States.
  • Kumaragurubaran N; Department of Chemistry, Purdue University, West Lafayette, IN 47907, United States.
  • Huang X; Protein Studies Program, Oklahoma Medical Research Foundation, United States.
  • Tang J; Protein Studies Program, Oklahoma Medical Research Foundation, United States; Department of Biochemistry and Molecular Biology, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, United States.
  • Mesecar AD; Department of Chemistry, Purdue University, West Lafayette, IN 47907, United States; Department of Biochemistry, Purdue University, West Lafayette, IN 47907, United States; Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, United States.
Bioorg Med Chem Lett ; 28(15): 2605-2610, 2018 08 15.
Article en En | MEDLINE | ID: mdl-29970308
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Inhibidores de Proteasas / Compuestos Bicíclicos con Puentes / Ácido Aspártico Endopeptidasas / Secretasas de la Proteína Precursora del Amiloide Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2018 Tipo del documento: Article
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Inhibidores de Proteasas / Compuestos Bicíclicos con Puentes / Ácido Aspártico Endopeptidasas / Secretasas de la Proteína Precursora del Amiloide Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2018 Tipo del documento: Article