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Associations Between the Features of Gross Placental Morphology and Birthweight.
Freedman, Alexa A; Hogue, Carol J; Marsit, Carmen J; Rajakumar, Augustine; Smith, Alicia K; Goldenberg, Robert L; Dudley, Donald J; Saade, George R; Silver, Robert M; Gibbins, Karen J; Stoll, Barbara J; Bukowski, Radek; Drews-Botsch, Carolyn.
Afiliación
  • Freedman AA; 1 Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia.
  • Hogue CJ; 1 Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia.
  • Marsit CJ; 1 Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia.
  • Rajakumar A; 2 Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia.
  • Smith AK; 3 Department of Gynecology and Obstetrics, School of Medicine, Emory University, Atlanta, Georgia.
  • Goldenberg RL; 3 Department of Gynecology and Obstetrics, School of Medicine, Emory University, Atlanta, Georgia.
  • Dudley DJ; 4 Department of Obstetrics and Gynecology, Columbia University Medical Center, New York, New York.
  • Saade GR; 5 Department of Obstetrics and Gynecology, School of Medicine, University of Virginia, Charlottesville, Virginia.
  • Silver RM; 6 Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas.
  • Gibbins KJ; 7 Department of Obstetrics and Gynecology, School of Medicine, University of Utah, Salt Lake City, Utah.
  • Stoll BJ; 7 Department of Obstetrics and Gynecology, School of Medicine, University of Utah, Salt Lake City, Utah.
  • Bukowski R; 8 McGovern Medical School, University of Texas Health Science Center, Houston, Texas.
  • Drews-Botsch C; 9 Department of Women's Health, Dell Medical School, University of Texas at Austin, Austin, Texas.
Pediatr Dev Pathol ; 22(3): 194-204, 2019.
Article en En | MEDLINE | ID: mdl-30012074
The placenta plays a critical role in regulating fetal growth. Recent studies suggest that there may be sex-specific differences in placental development. The purpose of our study was to evaluate the associations between birthweight and placental morphology in models adjusted for covariates and to assess sex-specific differences in these associations. We analyzed data from the Stillbirth Collaborative Research Network's population-based case-control study conducted between 2006 and 2008, which recruited cases of stillbirth and population-based controls in 5 states. Our analysis was restricted to singleton live births with a placental examination (n = 1229). Characteristics of placental morphology evaluated include thickness, surface area, difference in diameters, shape, and umbilical cord insertion site. We used linear regression to model birthweight as a function of placental morphology and covariates. Surface area had the greatest association with birthweight; a reduction in surface area of 83 cm2, which reflects the interquartile range, is associated with a 260.2-g reduction in birthweight (95% confidence interval, -299.9 to -220.6), after adjustment for other features of placental morphology and covariates. Reduced placental thickness was also associated with lower birthweight. These associations did not differ between males and females. Our results suggest that reduced placental thickness and surface area are independently associated with lower birthweight and that these relationships are not related to sex.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Placenta / Peso al Nacer Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Newborn / Pregnancy Idioma: En Revista: Pediatr Dev Pathol Asunto de la revista: PATOLOGIA / PEDIATRIA Año: 2019 Tipo del documento: Article País de afiliación: Georgia

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Placenta / Peso al Nacer Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Newborn / Pregnancy Idioma: En Revista: Pediatr Dev Pathol Asunto de la revista: PATOLOGIA / PEDIATRIA Año: 2019 Tipo del documento: Article País de afiliación: Georgia