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Delineating the role of cooperativity in the design of potent PROTACs for BTK.
Zorba, Adelajda; Nguyen, Chuong; Xu, Yingrong; Starr, Jeremy; Borzilleri, Kris; Smith, James; Zhu, Hongyao; Farley, Kathleen A; Ding, WeiDong; Schiemer, James; Feng, Xidong; Chang, Jeanne S; Uccello, Daniel P; Young, Jennifer A; Garcia-Irrizary, Carmen N; Czabaniuk, Lara; Schuff, Brandon; Oliver, Robert; Montgomery, Justin; Hayward, Matthew M; Coe, Jotham; Chen, Jinshan; Niosi, Mark; Luthra, Suman; Shah, Jaymin C; El-Kattan, Ayman; Qiu, Xiayang; West, Graham M; Noe, Mark C; Shanmugasundaram, Veerabahu; Gilbert, Adam M; Brown, Matthew F; Calabrese, Matthew F.
Afiliación
  • Zorba A; Internal Medicine Research Unit, Pfizer Worldwide Research and Development, Cambridge, MA 02139.
  • Nguyen C; Discovery Sciences, Pfizer Worldwide Research and Development, Groton, CT 06340.
  • Xu Y; Discovery Sciences, Pfizer Worldwide Research and Development, Groton, CT 06340.
  • Starr J; Discovery Sciences, Pfizer Worldwide Research and Development, Groton, CT 06340.
  • Borzilleri K; Discovery Sciences, Pfizer Worldwide Research and Development, Groton, CT 06340.
  • Smith J; Discovery Sciences, Pfizer Worldwide Research and Development, Groton, CT 06340.
  • Zhu H; Discovery Sciences, Pfizer Worldwide Research and Development, Groton, CT 06340.
  • Farley KA; Computational Sciences, Medicinal Sciences, Pfizer Worldwide Research and Development, Groton, CT 06340.
  • Ding W; Discovery Sciences, Pfizer Worldwide Research and Development, Groton, CT 06340.
  • Schiemer J; Discovery Sciences, Pfizer Worldwide Research and Development, Groton, CT 06340.
  • Feng X; Discovery Sciences, Pfizer Worldwide Research and Development, Groton, CT 06340.
  • Chang JS; Discovery Sciences, Pfizer Worldwide Research and Development, Groton, CT 06340.
  • Uccello DP; Discovery Sciences, Pfizer Worldwide Research and Development, Groton, CT 06340.
  • Young JA; Discovery Sciences, Pfizer Worldwide Research and Development, Groton, CT 06340.
  • Garcia-Irrizary CN; Discovery Sciences, Pfizer Worldwide Research and Development, Groton, CT 06340.
  • Czabaniuk L; Discovery Sciences, Pfizer Worldwide Research and Development, Groton, CT 06340.
  • Schuff B; Discovery Sciences, Pfizer Worldwide Research and Development, Groton, CT 06340.
  • Oliver R; Discovery Sciences, Pfizer Worldwide Research and Development, Groton, CT 06340.
  • Montgomery J; Discovery Sciences, Pfizer Worldwide Research and Development, Groton, CT 06340.
  • Hayward MM; Discovery Sciences, Pfizer Worldwide Research and Development, Groton, CT 06340.
  • Coe J; Discovery Sciences, Pfizer Worldwide Research and Development, Groton, CT 06340.
  • Chen J; Discovery Sciences, Pfizer Worldwide Research and Development, Groton, CT 06340.
  • Niosi M; Discovery Sciences, Pfizer Worldwide Research and Development, Groton, CT 06340.
  • Luthra S; Medicine Design, Pfizer Worldwide Research and Development, Groton, CT 06340.
  • Shah JC; Pharmaceutical Sciences Small Molecule, Pfizer Worldwide Research and Development, Cambridge, MA 02139.
  • El-Kattan A; Pharmaceutical Sciences Small Molecule, Pfizer Worldwide Research and Development, Cambridge, MA 02139.
  • Qiu X; Medicine Design, Pfizer Worldwide Research and Development, Groton, CT 06340.
  • West GM; Discovery Sciences, Pfizer Worldwide Research and Development, Groton, CT 06340.
  • Noe MC; Discovery Sciences, Pfizer Worldwide Research and Development, Groton, CT 06340.
  • Shanmugasundaram V; Discovery Sciences, Pfizer Worldwide Research and Development, Groton, CT 06340.
  • Gilbert AM; Discovery Sciences, Pfizer Worldwide Research and Development, Groton, CT 06340.
  • Brown MF; Discovery Sciences, Pfizer Worldwide Research and Development, Groton, CT 06340.
  • Calabrese MF; Discovery Sciences, Pfizer Worldwide Research and Development, Groton, CT 06340.
Proc Natl Acad Sci U S A ; 115(31): E7285-E7292, 2018 07 31.
Article en En | MEDLINE | ID: mdl-30012605
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas Tirosina Quinasas / Ubiquitina-Proteína Ligasas / Ubiquitinación / Proteolisis Límite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2018 Tipo del documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas Tirosina Quinasas / Ubiquitina-Proteína Ligasas / Ubiquitinación / Proteolisis Límite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2018 Tipo del documento: Article