Transfer of miRNA in Macrophage-Derived Exosomes Induces Drug Resistance in Pancreatic Adenocarcinoma.

Binenbaum, Yoav; Fridman, Eran; Yaari, Zvi; Milman, Neta; Schroeder, Avi; Ben David, Gil; Shlomi, Tomer; Gil, Ziv

Binenbaum, Yoav; Fridman, Eran; Yaari, Zvi; Milman, Neta; Schroeder, Avi; Ben David, Gil; Shlomi, Tomer; Gil, Ziv.

Afiliación

Binenbaum Y; The Laboratory for Applied Cancer Research, Department of Otolaryngology Head and Neck Surgery, Clinical Research Institute at Rambam Healthcare Campus, Haifa, Israel.
Fridman E; The Laboratory for Applied Cancer Research, Department of Otolaryngology Head and Neck Surgery, Clinical Research Institute at Rambam Healthcare Campus, Haifa, Israel.
Yaari Z; Laboratory for Targeted Drug Delivery and Personalized Medicine Technologies, Technion, Israel Institute of Technology, Haifa, Israel.
Milman N; The Laboratory for Applied Cancer Research, Department of Otolaryngology Head and Neck Surgery, Clinical Research Institute at Rambam Healthcare Campus, Haifa, Israel.
Schroeder A; Laboratory for Targeted Drug Delivery and Personalized Medicine Technologies, Technion, Israel Institute of Technology, Haifa, Israel.
Ben David G; The Laboratory for Applied Cancer Research, Department of Otolaryngology Head and Neck Surgery, Clinical Research Institute at Rambam Healthcare Campus, Haifa, Israel.
Shlomi T; Departments of Computer Science and Biology, Technion, Israel Institute of Technology, Haifa, Israel.
Gil Z; The Laboratory for Applied Cancer Research, Department of Otolaryngology Head and Neck Surgery, Clinical Research Institute at Rambam Healthcare Campus, Haifa, Israel. G_Ziv@rambam.health.gov.il.

Cancer Res ; 78(18): 5287-5299, 2018 09 15.

Article en En | MEDLINE | ID: mdl-30042153

Asunto(s)

Adenocarcinoma/terapia; Carcinoma Ductal Pancreático/tratamiento farmacológico; Resistencia a Antineoplásicos; Exosomas/metabolismo; MicroARNs/metabolismo; Neoplasias Pancreáticas/terapia; Adenocarcinoma/metabolismo; Animales; Carcinoma Ductal Pancreático/metabolismo; Línea Celular Tumoral; Desoxicitidina/análogos & derivados; Desoxicitidina/farmacología; Modelos Animales de Enfermedad; Técnicas de Transferencia de Gen; Macrófagos Peritoneales/metabolismo; Ratones; Ratones Endogámicos C57BL; Ratones Noqueados; Neoplasias Pancreáticas/metabolismo; Microambiente Tumoral; Regulación hacia Arriba; Proteínas rab27 de Unión a GTP/genética; Gemcitabina

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Adenocarcinoma / Resistencia a Antineoplásicos / Carcinoma Ductal Pancreático / MicroARNs / Exosomas Límite: Animals Idioma: En Revista: Cancer Res Año: 2018 Tipo del documento: Article País de afiliación: Israel

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