Monosomy 7 in Pediatric Myelodysplastic Syndromes.
Hematol Oncol Clin North Am
; 32(4): 729-743, 2018 Aug.
Article
en En
| MEDLINE
| ID: mdl-30047423
ABSTRACT
Myelodysplastic syndromes (MDS) in children and adolescents are a rare heterogeneous group of clonal stem cell disorders. Complete or partial loss of chromosome 7 constitutes the most common cytogenetic abnormality encountered in any type of childhood MDS, is associated with more advanced disease, and usually requires a timely allogeneic stem cell transplantation. This article provides insights into the current understanding of the genotype, phenotype, and clonal evolution patterns in pediatric MDS associated with loss of chromosome 7.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Síndromes Mielodisplásicos
/
Deleción Cromosómica
/
Trasplante de Células Madre Hematopoyéticas
/
Evolución Clonal
Límite:
Adolescent
/
Child
/
Humans
Idioma:
En
Revista:
Hematol Oncol Clin North Am
Asunto de la revista:
HEMATOLOGIA
/
NEOPLASIAS
Año:
2018
Tipo del documento:
Article