Associations between low circulatory low-density lipoprotein cholesterol level and brain health in non-stroke non-demented subjects.
Neuroimage
; 181: 627-634, 2018 11 01.
Article
en En
| MEDLINE
| ID: mdl-30053515
ABSTRACT
Low-density lipoprotein cholesterol (LDL-C) and hypertension have independent and synergistic effects on atherosclerotic cardiovascular disease. However, the role of circulatory LDL-C and its possible interactions with hypertension in brain health have been poorly investigated. The study aimed to investigate the relationship between the circulatory LDL-C level and (1) brain structures, grey-matter volume (GMV) and white matter hyperintensity (WMH) and (2) cognitive functions, and whether hypertension plays a role in these relationships. Subjects who were non-stroke and non-demented were prospectively recruited from the community-based I-Lan Longitudinal Aging Study. High-resolution 3T MRI was performed with GM and WMH segmentation. GMVs, total and regional including Alzheimer's disease-susceptible area, and WMH volumes were measured. Neurological tests including verbal memory, visuospatial, and verbal executive functions were assessed. Eight-hundred-and-two participants (59.2⯱â¯5.7 years; 44% men) were included. Multivariate linear regression analyses showed that low circulatory LDL-C levels (<98â¯mg/dL) were significantly associated with reduced GMVs in frontal (standardized ßâ¯=â¯-0.130; pâ¯=â¯0.003) and posterior cingulate (ßâ¯=â¯-0.113; pâ¯=â¯0.032) regions in hypertensive but not normotensive subjects. In addition, low circulatory LDL-C levels, combined with hypertension, had the lowest posterior cingulate GMV (ßâ¯=â¯-0.073; pâ¯=â¯0.021), highest periventricular WMH (ßâ¯=â¯0.089; pâ¯=â¯0.011) and lowest verbal memory test scores (ßâ¯=â¯-0.088; pâ¯=â¯0.035) compared with neither low circulatory LDL-C level nor hypertension, and either hypertension or low circulatory LDL-C level. Age, sex, total intracranial volume, vascular risk factors, level of other circulatory lipids, and the taking of anti-hypertensive and lipid-lowering medications were adjusted. In conclusion, the role of circulatory LDL-C level and its interactive effect with hypertension on brain health are firstly demonstrated. A low circulatory LDL-C level was associated with reduced regional brain GMVs in hypertensive but not normotensive subjects. In addition, there seems a combined detrimental-effect of low circulatory LDL-C levels with hypertension on posterior cingulate GMV, WMH, and verbal memory.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Envejecimiento
/
Disfunción Cognitiva
/
Sustancia Gris
/
Sustancia Blanca
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Hipertensión
/
LDL-Colesterol
/
Memoria
Tipo de estudio:
Risk_factors_studies
Límite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Neuroimage
Asunto de la revista:
DIAGNOSTICO POR IMAGEM
Año:
2018
Tipo del documento:
Article