Increased Afterload Augments Sunitinib-Induced Cardiotoxicity in an Engineered Cardiac Microtissue Model.

Truitt, Rachel; Mu, Anbin; Corbin, Elise A; Vite, Alexia; Brandimarto, Jeffrey; Ky, Bonnie; Margulies, Kenneth B

Truitt, Rachel; Mu, Anbin; Corbin, Elise A; Vite, Alexia; Brandimarto, Jeffrey; Ky, Bonnie; Margulies, Kenneth B.

Afiliación

Truitt R; Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, Pennsylvania.
Mu A; Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Corbin EA; Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Vite A; Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Brandimarto J; Department of Mechanical Engineering and Applied Mechanics, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, Pennsylvania.
Ky B; Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Margulies KB; Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

JACC Basic Transl Sci ; 3(2): 265-276, 2018 Apr.

Article en En | MEDLINE | ID: mdl-30062212

Palabras clave

2D, 2-dimensional; 3D, 3-dimensional; AICAR, 5-aminoimidazole-4-carboxamide 1-ß-D-ribofuranoside; AMPK, adenosine monophosphate-activated protein kinase; ATP, adenosine triphosphate; CCCP, carbonyl cyanide m-chlorophenyl hydrazine; CMT, cardiac microtissue; DMSO, dimethyl sulfoxide; EDTA, ethylenediamine tetraacetic acid; Hu-iPS-CM, human induced pluripotent stem cell cardiomyocyte; LV, left ventricle; NRVM, neonatal rat ventricular myocyte; PDMS, polydimethylsiloxane; RPMI, Roswell Park Memorial Institute medium; TMRM, tetramethylrhodamine; afterload; apoptosis; cardiotoxicity; huMSC, human mesenchymal stem cell; iPS-CM, induced pluripotent stem cell-derived cardiomyocyte; sunitinib; tissue engineering; toxicology; tyrosine kinase inhibitors

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: JACC Basic Transl Sci Año: 2018 Tipo del documento: Article

Texto completo

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PubMed Links

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: JACC Basic Transl Sci Año: 2018 Tipo del documento: Article