A new HTLV-III/LAV protein encoded by a gene found in cytopathic retroviruses.
Science
; 231(4745): 1546-9, 1986 Mar 28.
Article
en En
| MEDLINE
| ID: mdl-3006243
ABSTRACT
The DNA of the HTLV-III/LAV group of retroviruses contains certain additional open reading frames that are not found in typical avian or mammalian retroviruses. The role of these sequences in encoding for gene products that may be related to pathogenesis remains to be resolved. An open reading frame whose 5' end overlaps with the pol gene, but is unrelated to the env gene, has been observed in HTLV-III/LAV and visna virus, both cytopathic mammalian retroviruses. Evidence presented here shows that this open reading frame is a bona fide coding sequence of HTLV-III/LAV and that its product, a protein with a molecular weight of 23,000, induces antibody production in the natural course of infection.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Proteínas de los Retroviridae
/
Deltaretrovirus
/
Genes Virales
/
Antígenos Virales
Idioma:
En
Revista:
Science
Año:
1986
Tipo del documento:
Article