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Discovery of 1-((6-Aminopyridin-3-yl)Methyl)-3-(4-Bromophenyl)Urea as a Potent, Irreversible Myeloperoxidase Inhibitor.
Marro, Martin L; Patterson, Andrew W; Lee, Lac; Deng, Lin; Reynolds, Aimee; Ren, Xianglin; Axford, Laura; Patnaik, Anup; Hollis-Symynkywicz, Micah; Casson, Nigel; Custeau, Dominique; Ames, Lisa; Loi, Sally; Zhang, Lihe; Honda, Toshiyuki; Blank, Jutta; Harrison, Tyler J; Papillon, Julien P N; Hamann, Lawrence G; Marcinkeviciene, Jovita; Regard, Jean B.
Afiliación
  • Marro ML; Cardiovascular and Metabolic Diseases (M.L.M., L.L., X.R., L.Ax., M.H.-S., N.C., D.C., L.Am., S.L., L.Z., T.H., J.M., J.B.R.), Global Discovery Chemistry (A.W.P., A.P., T.J.H., J.P.N.P., L.G.H.), PK Sciences (L.D.), Technical R&D (A.R.), and Chemical Biology and Therapeutics (J.B.), Novartis Ins
  • Patterson AW; Cardiovascular and Metabolic Diseases (M.L.M., L.L., X.R., L.Ax., M.H.-S., N.C., D.C., L.Am., S.L., L.Z., T.H., J.M., J.B.R.), Global Discovery Chemistry (A.W.P., A.P., T.J.H., J.P.N.P., L.G.H.), PK Sciences (L.D.), Technical R&D (A.R.), and Chemical Biology and Therapeutics (J.B.), Novartis Ins
  • Lee L; Cardiovascular and Metabolic Diseases (M.L.M., L.L., X.R., L.Ax., M.H.-S., N.C., D.C., L.Am., S.L., L.Z., T.H., J.M., J.B.R.), Global Discovery Chemistry (A.W.P., A.P., T.J.H., J.P.N.P., L.G.H.), PK Sciences (L.D.), Technical R&D (A.R.), and Chemical Biology and Therapeutics (J.B.), Novartis Ins
  • Deng L; Cardiovascular and Metabolic Diseases (M.L.M., L.L., X.R., L.Ax., M.H.-S., N.C., D.C., L.Am., S.L., L.Z., T.H., J.M., J.B.R.), Global Discovery Chemistry (A.W.P., A.P., T.J.H., J.P.N.P., L.G.H.), PK Sciences (L.D.), Technical R&D (A.R.), and Chemical Biology and Therapeutics (J.B.), Novartis Ins
  • Reynolds A; Cardiovascular and Metabolic Diseases (M.L.M., L.L., X.R., L.Ax., M.H.-S., N.C., D.C., L.Am., S.L., L.Z., T.H., J.M., J.B.R.), Global Discovery Chemistry (A.W.P., A.P., T.J.H., J.P.N.P., L.G.H.), PK Sciences (L.D.), Technical R&D (A.R.), and Chemical Biology and Therapeutics (J.B.), Novartis Ins
  • Ren X; Cardiovascular and Metabolic Diseases (M.L.M., L.L., X.R., L.Ax., M.H.-S., N.C., D.C., L.Am., S.L., L.Z., T.H., J.M., J.B.R.), Global Discovery Chemistry (A.W.P., A.P., T.J.H., J.P.N.P., L.G.H.), PK Sciences (L.D.), Technical R&D (A.R.), and Chemical Biology and Therapeutics (J.B.), Novartis Ins
  • Axford L; Cardiovascular and Metabolic Diseases (M.L.M., L.L., X.R., L.Ax., M.H.-S., N.C., D.C., L.Am., S.L., L.Z., T.H., J.M., J.B.R.), Global Discovery Chemistry (A.W.P., A.P., T.J.H., J.P.N.P., L.G.H.), PK Sciences (L.D.), Technical R&D (A.R.), and Chemical Biology and Therapeutics (J.B.), Novartis Ins
  • Patnaik A; Cardiovascular and Metabolic Diseases (M.L.M., L.L., X.R., L.Ax., M.H.-S., N.C., D.C., L.Am., S.L., L.Z., T.H., J.M., J.B.R.), Global Discovery Chemistry (A.W.P., A.P., T.J.H., J.P.N.P., L.G.H.), PK Sciences (L.D.), Technical R&D (A.R.), and Chemical Biology and Therapeutics (J.B.), Novartis Ins
  • Hollis-Symynkywicz M; Cardiovascular and Metabolic Diseases (M.L.M., L.L., X.R., L.Ax., M.H.-S., N.C., D.C., L.Am., S.L., L.Z., T.H., J.M., J.B.R.), Global Discovery Chemistry (A.W.P., A.P., T.J.H., J.P.N.P., L.G.H.), PK Sciences (L.D.), Technical R&D (A.R.), and Chemical Biology and Therapeutics (J.B.), Novartis Ins
  • Casson N; Cardiovascular and Metabolic Diseases (M.L.M., L.L., X.R., L.Ax., M.H.-S., N.C., D.C., L.Am., S.L., L.Z., T.H., J.M., J.B.R.), Global Discovery Chemistry (A.W.P., A.P., T.J.H., J.P.N.P., L.G.H.), PK Sciences (L.D.), Technical R&D (A.R.), and Chemical Biology and Therapeutics (J.B.), Novartis Ins
  • Custeau D; Cardiovascular and Metabolic Diseases (M.L.M., L.L., X.R., L.Ax., M.H.-S., N.C., D.C., L.Am., S.L., L.Z., T.H., J.M., J.B.R.), Global Discovery Chemistry (A.W.P., A.P., T.J.H., J.P.N.P., L.G.H.), PK Sciences (L.D.), Technical R&D (A.R.), and Chemical Biology and Therapeutics (J.B.), Novartis Ins
  • Ames L; Cardiovascular and Metabolic Diseases (M.L.M., L.L., X.R., L.Ax., M.H.-S., N.C., D.C., L.Am., S.L., L.Z., T.H., J.M., J.B.R.), Global Discovery Chemistry (A.W.P., A.P., T.J.H., J.P.N.P., L.G.H.), PK Sciences (L.D.), Technical R&D (A.R.), and Chemical Biology and Therapeutics (J.B.), Novartis Ins
  • Loi S; Cardiovascular and Metabolic Diseases (M.L.M., L.L., X.R., L.Ax., M.H.-S., N.C., D.C., L.Am., S.L., L.Z., T.H., J.M., J.B.R.), Global Discovery Chemistry (A.W.P., A.P., T.J.H., J.P.N.P., L.G.H.), PK Sciences (L.D.), Technical R&D (A.R.), and Chemical Biology and Therapeutics (J.B.), Novartis Ins
  • Zhang L; Cardiovascular and Metabolic Diseases (M.L.M., L.L., X.R., L.Ax., M.H.-S., N.C., D.C., L.Am., S.L., L.Z., T.H., J.M., J.B.R.), Global Discovery Chemistry (A.W.P., A.P., T.J.H., J.P.N.P., L.G.H.), PK Sciences (L.D.), Technical R&D (A.R.), and Chemical Biology and Therapeutics (J.B.), Novartis Ins
  • Honda T; Cardiovascular and Metabolic Diseases (M.L.M., L.L., X.R., L.Ax., M.H.-S., N.C., D.C., L.Am., S.L., L.Z., T.H., J.M., J.B.R.), Global Discovery Chemistry (A.W.P., A.P., T.J.H., J.P.N.P., L.G.H.), PK Sciences (L.D.), Technical R&D (A.R.), and Chemical Biology and Therapeutics (J.B.), Novartis Ins
  • Blank J; Cardiovascular and Metabolic Diseases (M.L.M., L.L., X.R., L.Ax., M.H.-S., N.C., D.C., L.Am., S.L., L.Z., T.H., J.M., J.B.R.), Global Discovery Chemistry (A.W.P., A.P., T.J.H., J.P.N.P., L.G.H.), PK Sciences (L.D.), Technical R&D (A.R.), and Chemical Biology and Therapeutics (J.B.), Novartis Ins
  • Harrison TJ; Cardiovascular and Metabolic Diseases (M.L.M., L.L., X.R., L.Ax., M.H.-S., N.C., D.C., L.Am., S.L., L.Z., T.H., J.M., J.B.R.), Global Discovery Chemistry (A.W.P., A.P., T.J.H., J.P.N.P., L.G.H.), PK Sciences (L.D.), Technical R&D (A.R.), and Chemical Biology and Therapeutics (J.B.), Novartis Ins
  • Papillon JPN; Cardiovascular and Metabolic Diseases (M.L.M., L.L., X.R., L.Ax., M.H.-S., N.C., D.C., L.Am., S.L., L.Z., T.H., J.M., J.B.R.), Global Discovery Chemistry (A.W.P., A.P., T.J.H., J.P.N.P., L.G.H.), PK Sciences (L.D.), Technical R&D (A.R.), and Chemical Biology and Therapeutics (J.B.), Novartis Ins
  • Hamann LG; Cardiovascular and Metabolic Diseases (M.L.M., L.L., X.R., L.Ax., M.H.-S., N.C., D.C., L.Am., S.L., L.Z., T.H., J.M., J.B.R.), Global Discovery Chemistry (A.W.P., A.P., T.J.H., J.P.N.P., L.G.H.), PK Sciences (L.D.), Technical R&D (A.R.), and Chemical Biology and Therapeutics (J.B.), Novartis Ins
  • Marcinkeviciene J; Cardiovascular and Metabolic Diseases (M.L.M., L.L., X.R., L.Ax., M.H.-S., N.C., D.C., L.Am., S.L., L.Z., T.H., J.M., J.B.R.), Global Discovery Chemistry (A.W.P., A.P., T.J.H., J.P.N.P., L.G.H.), PK Sciences (L.D.), Technical R&D (A.R.), and Chemical Biology and Therapeutics (J.B.), Novartis Ins
  • Regard JB; Cardiovascular and Metabolic Diseases (M.L.M., L.L., X.R., L.Ax., M.H.-S., N.C., D.C., L.Am., S.L., L.Z., T.H., J.M., J.B.R.), Global Discovery Chemistry (A.W.P., A.P., T.J.H., J.P.N.P., L.G.H.), PK Sciences (L.D.), Technical R&D (A.R.), and Chemical Biology and Therapeutics (J.B.), Novartis Ins
J Pharmacol Exp Ther ; 367(1): 147-154, 2018 10.
Article en En | MEDLINE | ID: mdl-30076263
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Peroxidasa / Inhibidores Enzimáticos / Aminopiridinas Límite: Animals / Humans / Male Idioma: En Revista: J Pharmacol Exp Ther Año: 2018 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Peroxidasa / Inhibidores Enzimáticos / Aminopiridinas Límite: Animals / Humans / Male Idioma: En Revista: J Pharmacol Exp Ther Año: 2018 Tipo del documento: Article