Sensors and signals: the role of reactive oxygen species in hypoxic pulmonary vasoconstriction.
J Physiol
; 597(4): 1033-1043, 2019 02.
Article
en En
| MEDLINE
| ID: mdl-30091476
ABSTRACT
When lung cells experience hypoxia, the functional response, termed hypoxic pulmonary vasoconstriction, activates a multitude of pathways with the goal of optimizing gas exchange. While previously controversial, overwhelming evidence now suggests that increased reactive oxygen species - produced at complex III of the mitochondrial electron transport chain and released into the intermembrane space - is the cellular oxygen signal responsible for triggering hypoxic pulmonary vasoconstriction. The increased reactive oxygen species (ROS) activate many downstream targets that ultimately lead to increased intracellular ionized calcium concentration and contraction of pulmonary arterial smooth muscle cells. While the specific targets of ROS signals are not completely understood, it is clear that this signalling pathway is critical for development and for normal lung function in newborns and adults.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Vasoconstricción
/
Especies Reactivas de Oxígeno
/
Pulmón
/
Hipoxia
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Physiol
Año:
2019
Tipo del documento:
Article
País de afiliación:
Estados Unidos