A Small-Molecule Compound Has Anti-influenza A Virus Activity by Acting as a ''PB2 Inhibitor".

Liu, Teng; Liu, Miaomiao; Chen, Feimin; Chen, Fangzhao; Tian, Yuanxin; Huang, Qi; Liu, Shuwen; Yang, Jie

Liu, Teng; Liu, Miaomiao; Chen, Feimin; Chen, Fangzhao; Tian, Yuanxin; Huang, Qi; Liu, Shuwen; Yang, Jie.

Afiliación

Liu T; Guangdong Provincial Key Laboratory of New Drug Screening, Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, School of Pharmaceutical Sciences , Southern Medical University , Guangzhou 510515 , China.
Liu M; Guangdong Provincial Key Laboratory of New Drug Screening, Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, School of Pharmaceutical Sciences , Southern Medical University , Guangzhou 510515 , China.
Chen F; Guangdong Provincial Key Laboratory of New Drug Screening, Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, School of Pharmaceutical Sciences , Southern Medical University , Guangzhou 510515 , China.
Chen F; Guangdong Provincial Key Laboratory of New Drug Screening, Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, School of Pharmaceutical Sciences , Southern Medical University , Guangzhou 510515 , China.
Tian Y; Guangdong Provincial Key Laboratory of New Drug Screening, Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, School of Pharmaceutical Sciences , Southern Medical University , Guangzhou 510515 , China.
Huang Q; Guangdong Provincial Key Laboratory of New Drug Screening, Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, School of Pharmaceutical Sciences , Southern Medical University , Guangzhou 510515 , China.
Liu S; Guangdong Provincial Key Laboratory of New Drug Screening, Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, School of Pharmaceutical Sciences , Southern Medical University , Guangzhou 510515 , China.
Yang J; Guangdong Provincial Key Laboratory of New Drug Screening, Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, School of Pharmaceutical Sciences , Southern Medical University , Guangzhou 510515 , China.

Mol Pharm ; 15(9): 4110-4120, 2018 09 04.

Article en En | MEDLINE | ID: mdl-30102858

Asunto(s)

Antivirales/farmacología; ARN Polimerasa Dependiente del ARN/antagonistas & inhibidores; Proteínas Virales/antagonistas & inhibidores; Células A549; Animales; Antivirales/química; Western Blotting; Línea Celular; Perros; Sinergismo Farmacológico; Células HEK293; Humanos; Subtipo H1N1 del Virus de la Influenza A/efectos de los fármacos; Subtipo H1N1 del Virus de la Influenza A/metabolismo; Subtipo H3N2 del Virus de la Influenza A/efectos de los fármacos; Subtipo H3N2 del Virus de la Influenza A/metabolismo; Subtipo H5N1 del Virus de la Influenza A/efectos de los fármacos; Subtipo H5N1 del Virus de la Influenza A/metabolismo; Subtipo H7N9 del Virus de la Influenza A/efectos de los fármacos; Subtipo H7N9 del Virus de la Influenza A/metabolismo; Microscopía Fluorescente; Simulación del Acoplamiento Molecular; Oseltamivir/química; Oseltamivir/farmacología; Reacción en Cadena en Tiempo Real de la Polimerasa; Resonancia por Plasmón de Superficie; Proteínas Virales/metabolismo; Replicación Viral/efectos de los fármacos; Zanamivir/química; Zanamivir/farmacología

Palabras clave

PB2; PB2 cap-binding inhibitor; influenza A virus; viral polymerase; virus replication

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Antivirales / Proteínas Virales / ARN Polimerasa Dependiente del ARN Tipo de estudio: Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Mol Pharm Asunto de la revista: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: China

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