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Inhibition of K-RAS4B by a Unique Mechanism of Action: Stabilizing Membrane-Dependent Occlusion of the Effector-Binding Site.
Fang, Zhenhao; Marshall, Christopher B; Nishikawa, Tadateru; Gossert, Alvar D; Jansen, Johanna M; Jahnke, Wolfgang; Ikura, Mitsuhiko.
Afiliación
  • Fang Z; Department of Medical Biophysics, University of Toronto, Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada.
  • Marshall CB; Department of Medical Biophysics, University of Toronto, Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada. Electronic address: cmarshal@uhnresearch.ca.
  • Nishikawa T; Department of Medical Biophysics, University of Toronto, Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada.
  • Gossert AD; Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Basel 4002, Switzerland; Institute for Molecular Biology and Biophysics, Department of Biology, ETH Zürich, Zürich 8093, Switzerland.
  • Jansen JM; Department of Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Emeryville, CA 94608, USA.
  • Jahnke W; Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Basel 4002, Switzerland.
  • Ikura M; Department of Medical Biophysics, University of Toronto, Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada. Electronic address: mikura@uhnresearch.ca.
Cell Chem Biol ; 25(11): 1327-1336.e4, 2018 11 15.
Article en En | MEDLINE | ID: mdl-30122370
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Piperidinas / Proteínas Proto-Oncogénicas p21(ras) / Inhibidores Enzimáticos / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: Cell Chem Biol Año: 2018 Tipo del documento: Article País de afiliación: Canadá
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Piperidinas / Proteínas Proto-Oncogénicas p21(ras) / Inhibidores Enzimáticos / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: Cell Chem Biol Año: 2018 Tipo del documento: Article País de afiliación: Canadá