Inflammatory stress in islet ß-cells: therapeutic implications for type 2 diabetes?
Curr Opin Pharmacol
; 43: 40-45, 2018 12.
Article
en En
| MEDLINE
| ID: mdl-30142486
ABSTRACT
Type 2 diabetes is a common complex disease. Relatively little is known about the underlying pathophysiology. Mild islet inflammation has been suggested to play a pathogenic role; here we review the available evidence. Mild islet inflammation is histologically detected in pancreas sections of type 2 diabetic patients. In experimental models, it can be triggered by excess nutrients, amyloid, lipopolysaccharide, and endoplasmic reticulum and oxidative stress. Transcriptome studies do not consistently identify pro-inflammatory gene expression signatures in type 2 diabetic islets, and genetic evidence calls into question the causality of inflammation. Several anti-inflammatory medications confer a modest glucose-lowering effect, supporting the role for inflammation in type 2 diabetes. Whether these anti-inflammatory therapies target inflammation in islets or in other metabolically relevant tissues remains unknown.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Pancreatitis
/
Estrés Oxidativo
/
Mediadores de Inflamación
/
Diabetes Mellitus Tipo 2
/
Células Secretoras de Insulina
/
Estrés del Retículo Endoplásmico
/
Hipoglucemiantes
Tipo de estudio:
Sysrev_observational_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Opin Pharmacol
Asunto de la revista:
FARMACOLOGIA
Año:
2018
Tipo del documento:
Article