The bovine papillomavirus distal "enhancer" is not cis essential for transformation or for plasmid maintenance.
Mol Cell Biol
; 5(11): 3310-5, 1985 Nov.
Article
en En
| MEDLINE
| ID: mdl-3018516
We constructed a mutant of bovine papillomavirus type 1 (BPV-1) DNA that lacked a transcriptional enhancer located 3' to the polyadenylation site of the early viral RNAs expressed in transformed cells. This mutant DNA, when separated from the procaryotic sequences, transforms mouse cells with an efficiency comparable to that of the full BPV-1 genome, and it exists as a stable multicopy plasmid in transformed cells. The BPV-1 distal enhancer suppresses the effects of a cis-inhibitory element in pML2 sequences but is not essential for the expression of the viral genes involved in cellular transformation or plasmid maintenance.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Papillomaviridae
/
Plásmidos
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Transformación Genética
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Transformación Celular Viral
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Genes Reguladores
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Elementos de Facilitación Genéticos
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Papillomavirus Bovino 1
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Genes Virales
Límite:
Animals
Idioma:
En
Revista:
Mol Cell Biol
Año:
1985
Tipo del documento:
Article