[Network Pharmacological Studies of Puerariae Radix in Improving Insulin Resistance].
Zhong Yao Cai
; 39(7): 1628-32, 2016 Jul.
Article
en Zh
| MEDLINE
| ID: mdl-30204366
ABSTRACT
Objective:
To investigate the active components and potential mechanism of Puerariae Radix in improving insulin resistance by using network pharmacological method.Methods:
Key target proteins related with insulin resistance were selected based on molecular docking technology, and then took the selected components with 31 target proteins of four pathways for docking. Meanwhile, component-target proteins network was established to network analysis by software Cytoscape 3. 2. 1.Results:
19 compounds had close interactions with four pathways such as AMPK. There were 13 compositions can verify through literature, which revealing that active ingredients and potential molecular mechanism of Puerariae Radix in improving insulin resistance, preliminarily.Conclusion:
The network pharmacological method is helpful to explore the possible active components in Puerariae Radix and elucidate the mechanism.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Resistencia a la Insulina
/
Pueraria
Idioma:
Zh
Revista:
Zhong Yao Cai
Asunto de la revista:
TERAPIAS COMPLEMENTARES
Año:
2016
Tipo del documento:
Article