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P-Glycoprotein (MDR1/ABCB1) Restricts Brain Penetration of the Bruton's Tyrosine Kinase Inhibitor Ibrutinib, While Cytochrome P450-3A (CYP3A) Limits Its Oral Bioavailability.
van Hoppe, Stéphanie; Rood, Johannes J M; Buil, Levi; Wagenaar, Els; Sparidans, Rolf W; Beijnen, Jos H; Schinkel, Alfred H.
Afiliación
  • van Hoppe S; Division of Pharmacology , The Netherlands Cancer Institute , 1066 CX Amsterdam , The Netherlands.
  • Rood JJM; Section of Pharmacoepidemiology & Clinical Pharmacology, Department of Pharmaceutical Sciences, Faculty of Science , Utrecht University , 3512 JE Utrecht , The Netherlands.
  • Buil L; Division of Pharmacology , The Netherlands Cancer Institute , 1066 CX Amsterdam , The Netherlands.
  • Wagenaar E; Division of Pharmacology , The Netherlands Cancer Institute , 1066 CX Amsterdam , The Netherlands.
  • Sparidans RW; Section of Pharmacoepidemiology & Clinical Pharmacology, Department of Pharmaceutical Sciences, Faculty of Science , Utrecht University , 3512 JE Utrecht , The Netherlands.
  • Beijnen JH; Division of Pharmacology , The Netherlands Cancer Institute , 1066 CX Amsterdam , The Netherlands.
  • Schinkel AH; Section of Pharmacoepidemiology & Clinical Pharmacology, Department of Pharmaceutical Sciences, Faculty of Science , Utrecht University , 3512 JE Utrecht , The Netherlands.
Mol Pharm ; 15(11): 5124-5134, 2018 11 05.
Article en En | MEDLINE | ID: mdl-30247919
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pirazoles / Pirimidinas / Barrera Hematoencefálica / Citocromo P-450 CYP3A / Antineoplásicos Límite: Animals Idioma: En Revista: Mol Pharm Asunto de la revista: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Países Bajos
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pirazoles / Pirimidinas / Barrera Hematoencefálica / Citocromo P-450 CYP3A / Antineoplásicos Límite: Animals Idioma: En Revista: Mol Pharm Asunto de la revista: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Países Bajos