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Antimalarial Lead-Optimization Studies on a 2,6-Imidazopyridine Series within a Constrained Chemical Space To Circumvent Atypical Dose-Response Curves against Multidrug Resistant Parasite Strains.
Le Manach, Claire; Paquet, Tanya; Wicht, Kathryn; Nchinda, Aloysius T; Brunschwig, Christel; Njoroge, Mathew; Gibhard, Liezl; Taylor, Dale; Lawrence, Nina; Wittlin, Sergio; Eyermann, Charles J; Basarab, Gregory S; Duffy, James; Fish, Paul V; Street, Leslie J; Chibale, Kelly.
Afiliación
  • Le Manach C; Drug Discovery and Development Center (H3D), Department of Chemistry , University of Cape Town , Rondebosch 7701 , South Africa.
  • Paquet T; Drug Discovery and Development Center (H3D), Department of Chemistry , University of Cape Town , Rondebosch 7701 , South Africa.
  • Wicht K; Drug Discovery and Development Center (H3D), Department of Chemistry , University of Cape Town , Rondebosch 7701 , South Africa.
  • Nchinda AT; Drug Discovery and Development Center (H3D), Department of Chemistry , University of Cape Town , Rondebosch 7701 , South Africa.
  • Brunschwig C; H3D, Division of Clinical Pharmacology, Department of Medicine , University of Cape Town , Observatory 7925 , South Africa.
  • Njoroge M; H3D, Division of Clinical Pharmacology, Department of Medicine , University of Cape Town , Observatory 7925 , South Africa.
  • Gibhard L; H3D, Division of Clinical Pharmacology, Department of Medicine , University of Cape Town , Observatory 7925 , South Africa.
  • Taylor D; H3D, Division of Clinical Pharmacology, Department of Medicine , University of Cape Town , Observatory 7925 , South Africa.
  • Lawrence N; H3D, Division of Clinical Pharmacology, Department of Medicine , University of Cape Town , Observatory 7925 , South Africa.
  • Wittlin S; Swiss Tropical and Public Health Institute , Socinstrasse 57 , 4002 Basel , Switzerland.
  • Eyermann CJ; University of Basel , 4003 Basel , Switzerland.
  • Basarab GS; Drug Discovery and Development Center (H3D), Department of Chemistry , University of Cape Town , Rondebosch 7701 , South Africa.
  • Duffy J; Drug Discovery and Development Center (H3D), Department of Chemistry , University of Cape Town , Rondebosch 7701 , South Africa.
  • Fish PV; Medicines for Malaria Venture, ICC , Route de Pré-Bois 20 , PO Box 1826, 1215 Geneva , Switzerland.
  • Street LJ; Alzheimer's Research UK, UCL Drug Discovery Institute, The Cruciform Building , University College London , Gower Street , London WC1E 6BT , U.K.
  • Chibale K; The Francis Crick Institute , 1 Midland Road , London NW1 1AT , U.K.
J Med Chem ; 61(20): 9371-9385, 2018 10 25.
Article en En | MEDLINE | ID: mdl-30256636
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Plasmodium falciparum / Piridinas / Resistencia a Múltiples Medicamentos / Imidazoles / Antimaláricos Límite: Animals Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2018 Tipo del documento: Article País de afiliación: Sudáfrica
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Plasmodium falciparum / Piridinas / Resistencia a Múltiples Medicamentos / Imidazoles / Antimaláricos Límite: Animals Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2018 Tipo del documento: Article País de afiliación: Sudáfrica