Predicting puberty in partial androgen insensitivity syndrome: Use of clinical and functional androgen receptor indices.

Lek, Ngee; Tadokoro-Cuccaro, Rieko; Whitchurch, Jonathan B; Mazumder, Bismoy; Miles, Harriet; Prentice, Philippa; Bunch, Trevor; Zielinska, Karolina; Metzler, Veronika; Mongan, Nigel P; Heery, David M; Hughes, Ieuan A

Lek, Ngee; Tadokoro-Cuccaro, Rieko; Whitchurch, Jonathan B; Mazumder, Bismoy; Miles, Harriet; Prentice, Philippa; Bunch, Trevor; Zielinska, Karolina; Metzler, Veronika; Mongan, Nigel P; Heery, David M; Hughes, Ieuan A.

Afiliación

Lek N; University of Cambridge, Department of Paediatrics, Cambridge, United Kingdom; KK Women's and Children's Hospital, Department of Paediatrics, Singapore; Duke-NUS Medical School, National University of Singapore, Singapore.
Tadokoro-Cuccaro R; University of Cambridge, Department of Paediatrics, Cambridge, United Kingdom.
Whitchurch JB; School of Pharmacy, University of Nottingham, United Kingdom.
Mazumder B; School of Pharmacy, University of Nottingham, United Kingdom.
Miles H; University of Cambridge, Department of Paediatrics, Cambridge, United Kingdom.
Prentice P; University of Cambridge, Department of Paediatrics, Cambridge, United Kingdom.
Bunch T; University of Cambridge, Department of Paediatrics, Cambridge, United Kingdom.
Zielinska K; University of Cambridge, Department of Paediatrics, Cambridge, United Kingdom.
Metzler V; School of Veterinary Medicine and Science, University of Nottingham, United Kingdom.
Mongan NP; School of Veterinary Medicine and Science, University of Nottingham, United Kingdom.
Heery DM; School of Pharmacy, University of Nottingham, United Kingdom.
Hughes IA; University of Cambridge, Department of Paediatrics, Cambridge, United Kingdom. Electronic address: iah1000@cam.ac.uk.

EBioMedicine ; 36: 401-409, 2018 Oct.

Article en En | MEDLINE | ID: mdl-30316867

Asunto(s)

Síndrome de Resistencia Androgénica/diagnóstico; Síndrome de Resistencia Androgénica/metabolismo; Pubertad/metabolismo; Receptores Androgénicos/metabolismo; Adolescente; Adulto; Alelos; Síndrome de Resistencia Androgénica/genética; Animales; Biomarcadores; Línea Celular; Expresión Génica; Genotipo; Humanos; Masculino; Mutación; Pubertad/genética; Receptores Androgénicos/genética; Adulto Joven

Palabras clave

Androgen insensitivity; Androgen receptor; External masculinisation score; Gynaecomastia; Mutation; Puberty outcome; Reporter assays; Sex assignment; in silico modelling

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Síndrome de Resistencia Androgénica / Receptores Androgénicos / Pubertad Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Animals / Humans / Male Idioma: En Revista: EBioMedicine Año: 2018 Tipo del documento: Article País de afiliación: Singapur

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