Chemical approaches for the enhancement of 5-aminolevulinic acid-based photodynamic therapy and photodiagnosis.
Photochem Photobiol Sci
; 17(11): 1553-1572, 2018 Nov 01.
Article
en En
| MEDLINE
| ID: mdl-30328459
ABSTRACT
The administration of 5-aminolevulinic acid (ALA) to generate enhanced intracellular levels of endogenous porphyrins is currently one of the most important approaches for photodynamic therapy (PDT) and photodiagnosis (PDD). Despite the great promise of ALA-based PDT, the physicochemical behaviour and chemical reactivity of ALA are problematic, and a variety of chemical approaches have been brought to bear to improve cellular delivery, enhance porphyrin production, and generate ALA prodrugs that have appropriate stability for convenient clinical use, as well as selectivity for cancerous tissues. While there has been considerable success, there are still a number of challenges to be addressed and opportunities to be exploited through application of chemical insight in this area.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Fotoquimioterapia
/
Fármacos Fotosensibilizantes
/
Ácido Aminolevulínico
/
Neoplasias
/
Antineoplásicos
Límite:
Humans
Idioma:
En
Revista:
Photochem Photobiol Sci
Asunto de la revista:
BIOLOGIA
/
QUIMICA
Año:
2018
Tipo del documento:
Article
País de afiliación:
Reino Unido