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Characterization of a novel AICARFT inhibitor which potently elevates ZMP and has anti-tumor activity in murine models.
Brooks, Harold B; Meier, Timothy I; Geeganage, Sandaruwan; Fales, Kevin R; Thrasher, Kenneth J; Konicek, Susan A; Spencer, Charles D; Thibodeaux, Stefan; Foreman, Robert T; Hui, Yu-Hua; Roth, Kenneth D; Qian, Yue-Wei; Wang, Tao; Luo, Shuang; Torrado, Alicia; Si, Chong; Toth, James L; Mc Cowan, Jefferson R; Frimpong, Kwame; Lee, Matthew R; Dally, Robert D; Shepherd, Timothy A; Durham, Timothy B; Wang, Yong; Wu, Zhipei; Iversen, Philip W; Njoroge, F George.
Afiliación
  • Brooks HB; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA. brooks_harold@lilly.com.
  • Meier TI; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA.
  • Geeganage S; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA.
  • Fales KR; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA.
  • Thrasher KJ; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA.
  • Konicek SA; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA.
  • Spencer CD; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA.
  • Thibodeaux S; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA.
  • Foreman RT; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA.
  • Hui YH; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA.
  • Roth KD; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA.
  • Qian YW; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA.
  • Wang T; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA.
  • Luo S; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA.
  • Torrado A; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA.
  • Si C; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA.
  • Toth JL; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA.
  • Mc Cowan JR; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA.
  • Frimpong K; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA.
  • Lee MR; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA.
  • Dally RD; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA.
  • Shepherd TA; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA.
  • Durham TB; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA.
  • Wang Y; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA.
  • Wu Z; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA.
  • Iversen PW; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA.
  • Njoroge FG; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA.
Sci Rep ; 8(1): 15458, 2018 10 18.
Article en En | MEDLINE | ID: mdl-30337562
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Ribonucleótidos / Transferasas de Hidroximetilo y Formilo / Inhibidores Enzimáticos / Aminoimidazol Carboxamida / Neoplasias Pulmonares / Complejos Multienzimáticos / Proteínas de Neoplasias / Antineoplásicos / Nucleótido Desaminasas Límite: Animals / Female / Humans Idioma: En Revista: Sci Rep Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Ribonucleótidos / Transferasas de Hidroximetilo y Formilo / Inhibidores Enzimáticos / Aminoimidazol Carboxamida / Neoplasias Pulmonares / Complejos Multienzimáticos / Proteínas de Neoplasias / Antineoplásicos / Nucleótido Desaminasas Límite: Animals / Female / Humans Idioma: En Revista: Sci Rep Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos