Advanced glycation end products-related modulation of cathepsin L and NF-&#954;B signalling effectors in retinal pigment epithelium lead to augmented response to TNF&#945;.

Sharif, Umar; Mahmud, Nur Musfirah; Kay, Paul; Yang, Yit C; Harding, Simon P; Grierson, Ian; Kamalden, Tengku Ain; Jackson, Malcolm J; Paraoan, Luminita

Advanced glycation end products-related modulation of cathepsin L and NF-κB signalling effectors in retinal pigment epithelium lead to augmented response to TNFα.

Sharif, Umar; Mahmud, Nur Musfirah; Kay, Paul; Yang, Yit C; Harding, Simon P; Grierson, Ian; Kamalden, Tengku Ain; Jackson, Malcolm J; Paraoan, Luminita.

Afiliación

Sharif U; Department of Eye and Vision Science, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.
Mahmud NM; Department of Eye and Vision Science, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.
Kay P; Eye Research Centre, University of Malaya, Kuala Lumpur, Malaysia.
Yang YC; Department of Eye and Vision Science, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.
Harding SP; Ophthalmology, The Royal Wolverhampton NHS Trust, Wolverhampton, UK.
Grierson I; Department of Eye and Vision Science, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.
Kamalden TA; Department of Eye and Vision Science, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.
Jackson MJ; Eye Research Centre, University of Malaya, Kuala Lumpur, Malaysia.
Paraoan L; Department of Musculoskeletal Science, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.

J Cell Mol Med ; 23(1): 405-416, 2019 01.

Article en En | MEDLINE | ID: mdl-30338926

Asunto(s)

Catepsina L/metabolismo; Productos Finales de Glicación Avanzada/metabolismo; FN-kappa B/metabolismo; Epitelio Pigmentado de la Retina/metabolismo; Transducción de Señal/fisiología; Factor de Necrosis Tumoral alfa/metabolismo; Células Cultivadas; Humanos; Degeneración Macular/metabolismo

Palabras clave

age-related macular degeneration; cathepsin, NF-κB signalling; inflammation; proteolysis; retinal pigment epithelium

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Transducción de Señal / FN-kappa B / Factor de Necrosis Tumoral alfa / Productos Finales de Glicación Avanzada / Epitelio Pigmentado de la Retina / Catepsina L Límite: Humans Idioma: En Revista: J Cell Mol Med Asunto de la revista: BIOLOGIA MOLECULAR Año: 2019 Tipo del documento: Article País de afiliación: Reino Unido

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