3'-Deoxy-3'-[18F]Fluorothymidine Positron Emission Tomography Depicts Heterogeneous Proliferation Pathology in Idiopathic Pulmonary Arterial Hypertension Patient Lung.

Ashek, Ali; Spruijt, Onno A; Harms, Hendrik J; Lammertsma, Adriaan A; Cupitt, John; Dubois, Olivier; Wharton, John; Dabral, Swati; Pullamsetti, Soni Savai; Huisman, Marc C; Frings, Virginie; Boellaard, Ronald; de Man, Frances S; Botros, Lisa; Jansen, Samara; Vonk Noordegraaf, Anton; Wilkins, Martin R; Bogaard, Harm J; Zhao, Lan

Ashek, Ali; Spruijt, Onno A; Harms, Hendrik J; Lammertsma, Adriaan A; Cupitt, John; Dubois, Olivier; Wharton, John; Dabral, Swati; Pullamsetti, Soni Savai; Huisman, Marc C; Frings, Virginie; Boellaard, Ronald; de Man, Frances S; Botros, Lisa; Jansen, Samara; Vonk Noordegraaf, Anton; Wilkins, Martin R; Bogaard, Harm J; Zhao, Lan.

Afiliación

Ashek A; Center for Pharmacology and Therapeutics, Experimental Medicine, Hammersmith Hospital, Imperial College London, United Kingdom (A.A., J.C., O.D., J.W., M.R.W., L.Z.).
Spruijt OA; Department of Pulmonary Medicine (O.A.S., H.J.H., F.S.d.M., L.B., S.J., A.V.N., H.J.B.).
Harms HJ; Department of Pulmonary Medicine (O.A.S., H.J.H., F.S.d.M., L.B., S.J., A.V.N., H.J.B.).
Lammertsma AA; Department of Radiology and Nuclear Medicine (A.A.L., M.C.H., V.F., R.B., F.S.d.M.), VU University Medical Center, Amsterdam, the Netherlands.
Cupitt J; Center for Pharmacology and Therapeutics, Experimental Medicine, Hammersmith Hospital, Imperial College London, United Kingdom (A.A., J.C., O.D., J.W., M.R.W., L.Z.).
Dubois O; Center for Pharmacology and Therapeutics, Experimental Medicine, Hammersmith Hospital, Imperial College London, United Kingdom (A.A., J.C., O.D., J.W., M.R.W., L.Z.).
Wharton J; Center for Pharmacology and Therapeutics, Experimental Medicine, Hammersmith Hospital, Imperial College London, United Kingdom (A.A., J.C., O.D., J.W., M.R.W., L.Z.).
Dabral S; Max-Planck Institute for Heart and Lung Research, University of Giessen and Marburg Lung Center, German Center for Lung Research, Bad Nauheim (S.D., S.S.P.).
Pullamsetti SS; Max-Planck Institute for Heart and Lung Research, University of Giessen and Marburg Lung Center, German Center for Lung Research, Bad Nauheim (S.D., S.S.P.).
Huisman MC; Department of Radiology and Nuclear Medicine (A.A.L., M.C.H., V.F., R.B., F.S.d.M.), VU University Medical Center, Amsterdam, the Netherlands.
Frings V; Department of Radiology and Nuclear Medicine (A.A.L., M.C.H., V.F., R.B., F.S.d.M.), VU University Medical Center, Amsterdam, the Netherlands.
Boellaard R; Department of Radiology and Nuclear Medicine (A.A.L., M.C.H., V.F., R.B., F.S.d.M.), VU University Medical Center, Amsterdam, the Netherlands.
de Man FS; Department of Pulmonary Medicine (O.A.S., H.J.H., F.S.d.M., L.B., S.J., A.V.N., H.J.B.).
Botros L; Department of Radiology and Nuclear Medicine (A.A.L., M.C.H., V.F., R.B., F.S.d.M.), VU University Medical Center, Amsterdam, the Netherlands.
Jansen S; Department of Pulmonary Medicine (O.A.S., H.J.H., F.S.d.M., L.B., S.J., A.V.N., H.J.B.).
Vonk Noordegraaf A; Department of Pulmonary Medicine (O.A.S., H.J.H., F.S.d.M., L.B., S.J., A.V.N., H.J.B.).
Wilkins MR; Department of Pulmonary Medicine (O.A.S., H.J.H., F.S.d.M., L.B., S.J., A.V.N., H.J.B.).
Bogaard HJ; Center for Pharmacology and Therapeutics, Experimental Medicine, Hammersmith Hospital, Imperial College London, United Kingdom (A.A., J.C., O.D., J.W., M.R.W., L.Z.).
Zhao L; Department of Pulmonary Medicine (O.A.S., H.J.H., F.S.d.M., L.B., S.J., A.V.N., H.J.B.).

Circ Cardiovasc Imaging ; 11(8): e007402, 2018 08.

Article en En | MEDLINE | ID: mdl-30354494

Asunto(s)

Proliferación Celular; Didesoxinucleósidos/administración & dosificación; Hipertensión Pulmonar Primaria Familiar/diagnóstico por imagen; Pulmón/irrigación sanguínea; Tomografía de Emisión de Positrones/métodos; Arteria Pulmonar/diagnóstico por imagen; Radiofármacos/administración & dosificación; Remodelación Vascular; Adulto; Anciano; Animales; Estudios de Casos y Controles; Células Cultivadas; Didesoxinucleósidos/farmacocinética; Modelos Animales de Enfermedad; Tranportador Equilibrativo 1 de Nucleósido/metabolismo; Hipertensión Pulmonar Primaria Familiar/metabolismo; Hipertensión Pulmonar Primaria Familiar/patología; Hipertensión Pulmonar Primaria Familiar/fisiopatología; Femenino; Fibroblastos/metabolismo; Fibroblastos/patología; Humanos; Antígeno Ki-67/metabolismo; Masculino; Persona de Mediana Edad; Modelos Biológicos; Valor Predictivo de las Pruebas; Arteria Pulmonar/metabolismo; Arteria Pulmonar/patología; Arteria Pulmonar/fisiopatología; Radiofármacos/farmacocinética; Ratas Sprague-Dawley; Timidina Quinasa/metabolismo; Timidina Fosforilasa/metabolismo

Palabras clave

positron emission tomography; pulmonary hypertension; thymidine kinase 1; vascular remodeling

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Arteria Pulmonar / Didesoxinucleósidos / Radiofármacos / Tomografía de Emisión de Positrones / Proliferación Celular / Hipertensión Pulmonar Primaria Familiar / Remodelación Vascular / Pulmón Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Circ Cardiovasc Imaging Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA / DIAGNOSTICO POR IMAGEM Año: 2018 Tipo del documento: Article

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