Your browser doesn't support javascript.
loading
Management and treatment of children with medulloblastoma in Serbia, a middle-income country.
Bokun, Jelena; Grujicic, Danica; Skender-Gazibara, Milica; Paripovic, Lejla; Pekmezovic, Tatjana; Kisic-Tepavcevic, Darija; Ilic, Vesna; Raicevic, Savo; Stanic, Dragana; Miskovic, Ivana; Saric, Milan; Nikitovic, Marina.
Afiliación
  • Bokun J; Institute for Oncology and Radiology of Serbia, Clinic for Radiation Oncology, Belgrade, Serbia.
J BUON ; 23(4): 1156-1162, 2018.
Article en En | MEDLINE | ID: mdl-30358225
ABSTRACT

PURPOSE:

The aim of this study was to present the management and treatment of children with medulloblastoma in Serbia, a middle-income country (MIC).

METHODS:

The data of 87 children diagnosed with medulloblastoma and treated at the Institute for Oncology and Radiology of Serbia from 2000 to 2013 were analyzed.

RESULTS:

The children's median age was 8.3 years (range 2.5-17.3). Eighty-two (94.2%) were 3 years or older. Sixtytwo (71.3%) patients had stage M0 medulloblastoma, 12 (13.8%) had stage M1 and 13 (14.9%) had stage M2 or M3. As of October 2015, 51 (58.6%) patients were alive and 31 (35.6%) had died. Five patients (5.7%) were lost to followup. Twenty-six patients relapsed. The median follow-up time was 58 months (range 4-187). Mean overall survival (OS) was 76.4% at 3 years, 66.2% at 5 years and 59.2% at 10 years. Mean disease-free survival (DFS) was 75.8% at 3 years, 62.8% at 5 years and 56.6% at 10 years. Mean OS of stage M0 patients was 86.4% at 3 years, 74% at 5 years and 63.1% at 10 years. The OS of stage M1, M2 and M3 patients combined was 48.9% at 3 years, 44.0% at 5 years and 37.7% at 10 years.

CONCLUSION:

In Serbia, a MIC, it is possible to achieve good treatment results in children with medulloblastoma using international treatment guidelines and recommendations, available resources and an experienced team of professionals dedicated to pediatric neurooncology.
Asunto(s)
Buscar en Google
Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Cerebelosas / Meduloblastoma Tipo de estudio: Guideline / Prognostic_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Male País/Región como asunto: Europa Idioma: En Revista: J BUON Asunto de la revista: NEOPLASIAS Año: 2018 Tipo del documento: Article
Buscar en Google
Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Cerebelosas / Meduloblastoma Tipo de estudio: Guideline / Prognostic_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Male País/Región como asunto: Europa Idioma: En Revista: J BUON Asunto de la revista: NEOPLASIAS Año: 2018 Tipo del documento: Article