Integrating data gap filling techniques: A case study predicting TEFs for neurotoxicity TEQs to facilitate the hazard assessment of polychlorinated biphenyls.

Pradeep, Prachi; Carlson, Laura M; Judson, Richard; Lehmann, Geniece M; Patlewicz, Grace

Pradeep, Prachi; Carlson, Laura M; Judson, Richard; Lehmann, Geniece M; Patlewicz, Grace.

Afiliación

Pradeep P; Oak Ridge Institute for Science and Education, Oak Ridge, TN, USA; National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA.
Carlson LM; National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA.
Judson R; National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA.
Lehmann GM; National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA.
Patlewicz G; National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA. Electronic address: patlewicz.grace@epa.gov.

Regul Toxicol Pharmacol ; 101: 12-23, 2019 Feb.

Article en En | MEDLINE | ID: mdl-30359698

Asunto(s)

Contaminantes Ambientales/toxicidad; Síndromes de Neurotoxicidad; Bifenilos Policlorados/toxicidad; Animales; Encéfalo/metabolismo; Calcio/metabolismo; Dopamina/metabolismo; Contaminantes Ambientales/química; Células PC12; Bifenilos Policlorados/química; Proteína Quinasa C/metabolismo; Relación Estructura-Actividad Cuantitativa; Ratas; Medición de Riesgo; Canal Liberador de Calcio Receptor de Rianodina/metabolismo

Palabras clave

Neurotoxic equivalent factor (NEF); Neurotoxicity; PCB congeners; QSAR; Toxic equivalency factors (TEFs)

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Bifenilos Policlorados / Síndromes de Neurotoxicidad / Contaminantes Ambientales Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: Regul Toxicol Pharmacol Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos

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