Mouse genome-wide association studies and systems genetics uncover the genetic architecture associated with hepatic pharmacokinetic and pharmacodynamic properties of a constrained ethyl antisense oligonucleotide targeting Malat1.

Pirie, Elaine; Ray, Shayoni; Pan, Calvin; Fu, Wuxia; Powers, Andrew F; Polikoff, Danielle; Miller, Colton M; Kudrna, Katrina M; Harris, Edward N; Lusis, Aldons J; Crooke, Rosanne M; Lee, Richard G

Pirie, Elaine; Ray, Shayoni; Pan, Calvin; Fu, Wuxia; Powers, Andrew F; Polikoff, Danielle; Miller, Colton M; Kudrna, Katrina M; Harris, Edward N; Lusis, Aldons J; Crooke, Rosanne M; Lee, Richard G.

Afiliación

Pirie E; Cardiovascular Antisense Drug Discovery Group, Ionis Pharmaceuticals, Carlsbad, California, United States of America.
Ray S; Cardiovascular Antisense Drug Discovery Group, Ionis Pharmaceuticals, Carlsbad, California, United States of America.
Pan C; Department of Human Genetics, University of California, Los Angeles, Los Angeles, California, United States of America.
Fu W; Cardiovascular Antisense Drug Discovery Group, Ionis Pharmaceuticals, Carlsbad, California, United States of America.
Powers AF; Exploratory Drug Discovery Group, Ionis Pharmaceuticals, Carlsbad, California, United States of America.
Polikoff D; Cardiovascular Antisense Drug Discovery Group, Ionis Pharmaceuticals, Carlsbad, California, United States of America.
Miller CM; Department of Biochemistry, University of Nebraska-Lincoln, Lincoln, NE, United States of America.
Kudrna KM; Department of Biochemistry, University of Nebraska-Lincoln, Lincoln, NE, United States of America.
Harris EN; Department of Biochemistry, University of Nebraska-Lincoln, Lincoln, NE, United States of America.
Lusis AJ; Department of Human Genetics, University of California, Los Angeles, Los Angeles, California, United States of America.
Crooke RM; Cardiovascular Antisense Drug Discovery Group, Ionis Pharmaceuticals, Carlsbad, California, United States of America.
Lee RG; Cardiovascular Antisense Drug Discovery Group, Ionis Pharmaceuticals, Carlsbad, California, United States of America.

PLoS Genet ; 14(10): e1007732, 2018 10.

Article en En | MEDLINE | ID: mdl-30372444

Asunto(s)

Oligonucleótidos Antisentido/farmacocinética; ARN Largo no Codificante/genética; ARN Largo no Codificante/fisiología; Animales; Moléculas de Adhesión Celular Neuronal/genética; Moléculas de Adhesión Celular Neuronal/metabolismo; Perfilación de la Expresión Génica/métodos; Variación Genética; Estudio de Asociación del Genoma Completo; Hígado/metabolismo; Ratones; Ratones Noqueados; Oligonucleótidos Antisentido/genética; ARN Mensajero/metabolismo; Proteína 3 de Membrana Asociada a Vesículas/genética; Proteína 3 de Membrana Asociada a Vesículas/metabolismo

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Oligonucleótidos Antisentido / ARN Largo no Codificante Tipo de estudio: Risk_factors_studies Límite: Animals Idioma: En Revista: PLoS Genet Asunto de la revista: GENETICA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos

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