Is there any effect of montelukast on prevention of myringosclerosis after myringotomy in a rat model?
Eur Arch Otorhinolaryngol
; 276(1): 57-62, 2019 Jan.
Article
en En
| MEDLINE
| ID: mdl-30377759
ABSTRACT
OBJECTIVES:
In this study, our aim was to identify the possible effects of montelukast sodium (ML) on the prevention of experimentally induced myringosclerosis. MATERIALS ANDMETHODS:
Twenty-eight female Wistar albino rats were used and they were divided into four groups randomly. Tympanic membranes (TM) of all animals were perforated and then group 1 received no treatment (control group), group 2 was treated with a topical saline solution, group 3 received topically ML and group 4 received orally ML. On the 15th day, all animals were euthanized. Tympanic membranes were evaluated otomicroscopically and histopathologically.RESULTS:
The histopathological findings, compared against a control and saline groups, showed the topically and orally ML groups had statistically significant differences of degree of myringosclerosis (p < 0.002) and median thickness of the TMs (p < 0.001). Suppression of inflammation was statistically significant only in the oral ML treatment group (p < 0.002).CONCLUSION:
Oral and topically administration of ML reduced myringosclerosis formation in myringotomies rats.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Quinolinas
/
Membrana Timpánica
/
Ventilación del Oído Medio
/
Miringoesclerosis
/
Acetatos
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Eur Arch Otorhinolaryngol
Asunto de la revista:
OTORRINOLARINGOLOGIA
Año:
2019
Tipo del documento:
Article
País de afiliación:
Turquía