Photoresponsive, Water-Soluble Supramolecular Dendronized Polymer with Specific Lysosome-Targetable Bioimaging Application in Living Cells.
Macromol Rapid Commun
; 40(3): e1800714, 2019 Feb.
Article
en En
| MEDLINE
| ID: mdl-30408258
ABSTRACT
A novel photoresponsive, water-soluble supramolecular dendronized polymer (SDP) is prepared through a γ -cyclodextrin (γ -CD)-coumarin host-guest interaction. The supramolecular formation, photoresponsive process, and fluorescence properties are investigated by nuclear magnetic resonance (NMR) techniques and spectrometric measurements. Upon different-wavelength light irradiation, this supramolecular polymer undergoes noncovalent polymer and covalent polymer conversion due to coumarin cycloaddition and cleavage reactions. In addition, SDP for bioimaging in Michigan Cancer Foundation-7 (MCF-7) cells is performed and results show that the obtained SDP has good biocompatibility and is lysosome-targetable. This research enriches the field of supramolecular dendrimers and the photo-stimulation response material may have application prospects in organelle-targeting applications.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Polímeros
/
Agua
/
Dendrímeros
/
Lisosomas
Límite:
Humans
Idioma:
En
Revista:
Macromol Rapid Commun
Año:
2019
Tipo del documento:
Article