Human Cardiac Organoids for Disease Modeling.
Clin Pharmacol Ther
; 105(1): 79-85, 2019 01.
Article
en En
| MEDLINE
| ID: mdl-30415499
ABSTRACT
Human cardiac drug discovery and disease modeling face challenges in recapitulating cellular complexity and animal-to-human translation due to the limitations of conventional 2D cell culture and animal models. The development of human cardiac organoid technologies could help in stimulating and maintaining differentiated cell functions for extended periods of time. By closely mimicking in vivo organ functions in vitro they could thereby help in overcoming the obstacles mentioned above. Through the construction of human cardiac organoids from pluripotent stem cell-derived cells, derived from patients with specific known genotypes and phenotypes, more complex and robust in vitro tools have recently become available for disease modeling. In this review, we will describe the relevance and importance of evolving organoid platforms in disease biology. We further provide examples of cardiac organoid platforms, which may lead the way toward future personalized medicine and drug discovery.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Organoides
/
Miocitos Cardíacos
/
Células Madre Pluripotentes Inducidas
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Cardiopatías
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Clin Pharmacol Ther
Año:
2019
Tipo del documento:
Article
País de afiliación:
Suiza