Hyperglycemia promotes microvillus membrane expression of DMT1 in intestinal epithelial cells in a PKC&#945;-dependent manner.

Zhao, Luqing; Bartnikas, Thomas; Chu, Xiangpeng; Klein, Janet; Yun, Chris; Srinivasan, Shanthi; He, Peijian

Hyperglycemia promotes microvillus membrane expression of DMT1 in intestinal epithelial cells in a PKCα-dependent manner.

Zhao, Luqing; Bartnikas, Thomas; Chu, Xiangpeng; Klein, Janet; Yun, Chris; Srinivasan, Shanthi; He, Peijian.

Afiliación

Zhao L; Department of Gastroenterology, Beijing Hospital of Traditional Chinese Medicine Affiliated With Capital Medical University, Beijing, China.
Bartnikas T; Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Chu X; Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island, USA.
Klein J; Department of Thoracic Surgery, People's Hospital of Rizhao, Shandong, China.
Yun C; Division of Renal Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA; and.
Srinivasan S; Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
He P; Atlanta Veterans Administration Medical Center, Decatur, Georgia, USA.

FASEB J ; 33(3): 3549-3561, 2019 03.

Article en En | MEDLINE | ID: mdl-30423260

Asunto(s)

Duodeno/metabolismo; Células Epiteliales/metabolismo; Hiperglucemia/metabolismo; Microvellosidades/metabolismo; Proteína Quinasa C-alfa/metabolismo; Factores de Transcripción/metabolismo; Adulto; Anciano; Animales; Transporte Biológico/fisiología; Diabetes Mellitus Experimental/metabolismo; Glucosa/metabolismo; Humanos; Mucosa Intestinal/metabolismo; Hierro/metabolismo; Masculino; Proteínas de la Membrana/metabolismo; Ratones; Ratones Transgénicos/metabolismo; Persona de Mediana Edad; Ubiquitinación/fisiología

Palabras clave

HIF2α ubiquitination; diabetes; iron uptake

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Factores de Transcripción / Duodeno / Células Epiteliales / Proteína Quinasa C-alfa / Hiperglucemia / Microvellosidades Límite: Adult / Aged / Animals / Humans / Male / Middle aged Idioma: En Revista: FASEB J Asunto de la revista: BIOLOGIA / FISIOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: China

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