Your browser doesn't support javascript.
loading
Improved reference genome of Aedes aegypti informs arbovirus vector control.
Matthews, Benjamin J; Dudchenko, Olga; Kingan, Sarah B; Koren, Sergey; Antoshechkin, Igor; Crawford, Jacob E; Glassford, William J; Herre, Margaret; Redmond, Seth N; Rose, Noah H; Weedall, Gareth D; Wu, Yang; Batra, Sanjit S; Brito-Sierra, Carlos A; Buckingham, Steven D; Campbell, Corey L; Chan, Saki; Cox, Eric; Evans, Benjamin R; Fansiri, Thanyalak; Filipovic, Igor; Fontaine, Albin; Gloria-Soria, Andrea; Hall, Richard; Joardar, Vinita S; Jones, Andrew K; Kay, Raissa G G; Kodali, Vamsi K; Lee, Joyce; Lycett, Gareth J; Mitchell, Sara N; Muehling, Jill; Murphy, Michael R; Omer, Arina D; Partridge, Frederick A; Peluso, Paul; Aiden, Aviva Presser; Ramasamy, Vidya; Rasic, Gordana; Roy, Sourav; Saavedra-Rodriguez, Karla; Sharan, Shruti; Sharma, Atashi; Smith, Melissa Laird; Turner, Joe; Weakley, Allison M; Zhao, Zhilei; Akbari, Omar S; Black, William C; Cao, Han.
Afiliación
  • Matthews BJ; Laboratory of Neurogenetics and Behavior, The Rockefeller University, New York, NY, USA. bnmtthws@gmail.com.
  • Dudchenko O; Howard Hughes Medical Institute, New York, NY, USA. bnmtthws@gmail.com.
  • Kingan SB; Kavli Neural Systems Institute, New York, NY, USA. bnmtthws@gmail.com.
  • Koren S; The Center for Genome Architecture, Baylor College of Medicine, Houston, TX, USA.
  • Antoshechkin I; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
  • Crawford JE; Department of Computer Science, Rice University, Houston, TX, USA.
  • Glassford WJ; Center for Theoretical and Biological Physics, Rice University, Houston, TX, USA.
  • Herre M; Pacific Biosciences, Menlo Park, CA, USA.
  • Redmond SN; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • Rose NH; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
  • Weedall GD; Verily Life Sciences, South San Francisco, CA, USA.
  • Wu Y; Mortimer B. Zuckerman Mind Brain Behavior Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.
  • Batra SS; Laboratory of Neurogenetics and Behavior, The Rockefeller University, New York, NY, USA.
  • Brito-Sierra CA; Kavli Neural Systems Institute, New York, NY, USA.
  • Buckingham SD; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Campbell CL; Department of Immunology and Infectious Disease, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
  • Chan S; Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ, USA.
  • Cox E; Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
  • Evans BR; Vector Biology Department, Liverpool School of Tropical Medicine, Liverpool, UK.
  • Fansiri T; Liverpool John Moores University, Liverpool, UK.
  • Filipovic I; Department of Pathogen Biology, School of Public Health, Southern Medical University, Guangzhou, China.
  • Fontaine A; Department of Biochemistry, Virginia Tech, Blacksburg, VA, USA.
  • Gloria-Soria A; Fralin Life Science Institute, Virginia Tech, Blacksburg, VA, USA.
  • Hall R; The Center for Genome Architecture, Baylor College of Medicine, Houston, TX, USA.
  • Joardar VS; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
  • Jones AK; Department of Computer Science, Rice University, Houston, TX, USA.
  • Kay RGG; Department of Entomology, Purdue University, West Lafayette, IN, USA.
  • Kodali VK; Purdue Institute for Inflammation, Immunology and Infectious Disease, Purdue University, West Lafayette, IN, USA.
  • Lee J; Centre for Respiratory Biology, UCL Respiratory, University College London, London, UK.
  • Lycett GJ; Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.
  • Mitchell SN; Bionano Genomics, San Diego, CA, USA.
  • Muehling J; National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA.
  • Murphy MR; Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT, USA.
  • Omer AD; Vector Biology and Control Section, Department of Entomology, Armed Forces Research Institute of Medical Sciences (AFRIMS), Bangkok, Thailand.
  • Partridge FA; Mosquito Control Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
  • Peluso P; Insect-Virus Interactions Group, Department of Genomes and Genetics, Institut Pasteur, Paris, France.
  • Aiden AP; Unité de Parasitologie et Entomologie, Département des Maladies Infectieuses, Institut de Recherche Biomédicale des Armées, Marseille, France.
  • Ramasamy V; Centre National de la Recherche Scientifique, Unité Mixte de Recherche 2000, Paris, France.
  • Rasic G; Aix Marseille Université, IRD, AP-HM, SSA, UMR Vecteurs - Infections Tropicales et Méditerranéennes (VITROME), IHU - Méditerranée Infection, Marseille, France.
  • Roy S; Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT, USA.
  • Saavedra-Rodriguez K; The Connecticut Agricultural Experiment Station, New Haven, CT, USA.
  • Sharan S; Pacific Biosciences, Menlo Park, CA, USA.
  • Sharma A; National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA.
  • Smith ML; Department of Biological and Medical Sciences, Faculty of Health and Life Sciences, Oxford Brookes University, Oxford, UK.
  • Turner J; Department of Entomology, University of California Riverside, Riverside, CA, USA.
  • Weakley AM; National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA.
  • Zhao Z; Bionano Genomics, San Diego, CA, USA.
  • Akbari OS; Vector Biology Department, Liverpool School of Tropical Medicine, Liverpool, UK.
  • Black WC; Verily Life Sciences, South San Francisco, CA, USA.
  • Cao H; Pacific Biosciences, Menlo Park, CA, USA.
Nature ; 563(7732): 501-507, 2018 11.
Article en En | MEDLINE | ID: mdl-30429615
ABSTRACT
Female Aedes aegypti mosquitoes infect more than 400 million people each year with dangerous viral pathogens including dengue, yellow fever, Zika and chikungunya. Progress in understanding the biology of mosquitoes and developing the tools to fight them has been slowed by the lack of a high-quality genome assembly. Here we combine diverse technologies to produce the markedly improved, fully re-annotated AaegL5 genome assembly, and demonstrate how it accelerates mosquito science. We anchored physical and cytogenetic maps, doubled the number of known chemosensory ionotropic receptors that guide mosquitoes to human hosts and egg-laying sites, provided further insight into the size and composition of the sex-determining M locus, and revealed copy-number variation among glutathione S-transferase genes that are important for insecticide resistance. Using high-resolution quantitative trait locus and population genomic analyses, we mapped new candidates for dengue vector competence and insecticide resistance. AaegL5 will catalyse new biological insights and intervention strategies to fight this deadly disease vector.
Asunto(s)
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Infecciones por Arbovirus / Arbovirus / Control de Insectos / Aedes / Genómica / Genoma de los Insectos / Mosquitos Vectores Límite: Animals Idioma: En Revista: Nature Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Infecciones por Arbovirus / Arbovirus / Control de Insectos / Aedes / Genómica / Genoma de los Insectos / Mosquitos Vectores Límite: Animals Idioma: En Revista: Nature Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos