Successful resolution of Hemophagocytic lymphohistiocytosis associated to brucellosis in the adult.
Tunis Med
; 96(7): 458-461, 2018 Jul.
Article
en En
| MEDLINE
| ID: mdl-30430494
ABSTRACT
Hemophagocyticlymphohistocytosis (HLH) is a proliferation of histiocytes with importanthemophagocytosisoccurring in different organs such as the spleen and the bone marrow. HLH is now increasingly diagnosed in the context of infections, malignancies and connective tissue diseases. Although brucellosis is an endemic infection in Tunisia, its association with HLH is a very rare condition which should be considered in patients with splenomegaly and cytopenia. Here, we describe brucellosis associated HLH in a 31 year-old man. The patient was admitted to our hospital with fever, sweating, and fatigue. Physical and laboratory findings revealed splenomegaly, pancytopenia, elevated serum transaminases, triglycerides, lactate dehydrogenase, and ferritin, and bone marrow hemophagocytosis. The Brucella agglutination test was positive. The patient improved after treatment with Rifampin and doxycyclin.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Brucelosis
/
Linfohistiocitosis Hemofagocítica
Tipo de estudio:
Risk_factors_studies
Límite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Tunis Med
Año:
2018
Tipo del documento:
Article