Photorhabdus luminescens Tc toxin is inhibited by the protease inhibitor MG132 and activated by protease cleavage resulting in increased binding to target cells.

Ost, Gerhard Stefan; Ng'ang'a, Peter Njenga; Lang, Alexander E; Aktories, Klaus

Ost, Gerhard Stefan; Ng'ang'a, Peter Njenga; Lang, Alexander E; Aktories, Klaus.

Afiliación

Ost GS; Institute for Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Ng'ang'a PN; Faculty of Biology, University of Freiburg, Freiburg, Germany.
Lang AE; Institute for Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Aktories K; Faculty of Biology, University of Freiburg, Freiburg, Germany.

Cell Microbiol ; 21(3): e12978, 2019 03.

Article en En | MEDLINE | ID: mdl-30431706

Asunto(s)

Toxinas Bacterianas/toxicidad; Inhibidores de Cisteína Proteinasa/metabolismo; Leupeptinas/metabolismo; Photorhabdus/enzimología; Proteolisis; Toxinas Bacterianas/antagonistas & inhibidores; Toxinas Bacterianas/metabolismo; Péptido Hidrolasas/metabolismo; Unión Proteica

Palabras clave

ADP-ribosylation; MG132; Photorhabdus luminescens Tc toxins; calpain protease inhibitors; toxin processing

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Toxinas Bacterianas / Inhibidores de Cisteína Proteinasa / Photorhabdus / Proteolisis / Leupeptinas Idioma: En Revista: Cell Microbiol Asunto de la revista: MICROBIOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Alemania

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google