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Quantitative Modeling Analysis Demonstrates the Impact of CYP2C19 and CYP2D6 Genetic Polymorphisms on the Pharmacokinetics of Amitriptyline and Its Metabolite, Nortriptyline.
Koh, Ara; Pak, Kwan Cheol; Choi, Hee Youn; Ryu, Sunae; Choi, Seung-Eun; Kim, Ki Soon; Bae, Kyun-Seop; Lim, Hyeong-Seok.
Afiliación
  • Koh A; Department of Clinical Pharmacology and Therapeutics, Asan Medical Center, Seoul, Korea.
  • Pak KC; University of Ulsan College of Medicine, Seoul, Korea.
  • Choi HY; Department of Clinical Pharmacology and Therapeutics, Asan Medical Center, Seoul, Korea.
  • Ryu S; University of Ulsan College of Medicine, Seoul, Korea.
  • Choi SE; Department of Clinical Pharmacology and Therapeutics, Asan Medical Center, Seoul, Korea.
  • Kim KS; Clinical Research Division, National Institute of Food and Drug Safety Evaluation, Cheongju-si, Korea.
  • Bae KS; Clinical Research Division, National Institute of Food and Drug Safety Evaluation, Cheongju-si, Korea.
  • Lim HS; Clinical Research Division, National Institute of Food and Drug Safety Evaluation, Cheongju-si, Korea.
J Clin Pharmacol ; 59(4): 532-540, 2019 04.
Article en En | MEDLINE | ID: mdl-30452773
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Citocromo P-450 CYP2D6 / Citocromo P-450 CYP2C19 / Amitriptilina / Modelos Biológicos / Nortriptilina Límite: Adult / Humans / Male Idioma: En Revista: J Clin Pharmacol Año: 2019 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Citocromo P-450 CYP2D6 / Citocromo P-450 CYP2C19 / Amitriptilina / Modelos Biológicos / Nortriptilina Límite: Adult / Humans / Male Idioma: En Revista: J Clin Pharmacol Año: 2019 Tipo del documento: Article