Combined Genetic Effects of RET and NRG1 Susceptibility Variants on Multifactorial Hirschsprung Disease in Indonesia.
J Surg Res
; 233: 96-99, 2019 01.
Article
en En
| MEDLINE
| ID: mdl-30502294
ABSTRACT
BACKGROUND:
Specific genetic variants at RET (rs2435357) and NRG1 (rs7835688, rs16879552) are associated with Hirschsprung disease (HSCR) in Indonesia. This study aimed to investigate the additional effect of RET rs2506030 on these variants to determine its potential interactions in HSCR patients of Indonesian ancestry.METHODS:
Sixty HSCR patients and 122 non-HSCR controls were ascertained for this study and genotyped for RET rs2506030 using the TaqMan assay.RESULTS:
RET rs2506030 was associated with HSCR both by case-control analysis (odds ratio = 1.68; P = 0.043) and the transmission disequilibrium test (P = 0.034). Furthermore, individuals with five or six risk alleles at RET rs2506030, rs2435357 and NRG1 rs7835688 showed â¼45-fold higher HSCR risk than those with 0 or 1 or 2 risk alleles.CONCLUSIONS:
Disease risk of HSCR is increased by the combination of specific RET and NRG1 susceptibility variants.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Predisposición Genética a la Enfermedad
/
Neurregulina-1
/
Proteínas Proto-Oncogénicas c-ret
/
Enfermedad de Hirschsprung
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
/
Male
País/Región como asunto:
Asia
Idioma:
En
Revista:
J Surg Res
Año:
2019
Tipo del documento:
Article