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Discovery of potent azaindazole leucine-rich repeat kinase 2 (LRRK2) inhibitors possessing a key intramolecular hydrogen bond - Part 2.
Shore, Daniel G M; Sweeney, Zachary K; Beresford, Alan; Chan, Bryan K; Chen, Huifen; Drummond, Jason; Gill, Andrew; Kleinheinz, Tracy; Liu, Xingrong; Medhurst, Andrew D; McIver, Edward G; Moffat, John G; Zhu, Haitao; Estrada, Anthony A.
Afiliación
  • Shore DGM; Department of Discovery Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address: shore.daniel@gene.com.
  • Sweeney ZK; Department of Discovery Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Beresford A; Department of Drug Metabolism and Pharmacokinetics, BioFocus, Chesterford Research Park, Saffron Walden, Essex CB10 1XL, UK.
  • Chan BK; Department of Discovery Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Chen H; Department of Discovery Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Drummond J; Department of Biochemical and Cellular Pharmacology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Gill A; Department of Biochemical and Cellular Pharmacology, BioFocus, Chesterford Research Park, Saffron Walden, Essex CB10 1XL, UK.
  • Kleinheinz T; Department of Biochemical and Cellular Pharmacology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Liu X; Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Medhurst AD; Department of Biochemical and Cellular Pharmacology, BioFocus, Chesterford Research Park, Saffron Walden, Essex CB10 1XL, UK.
  • McIver EG; LifeArc, Accelerator Building, Open Innovation Campus, Stevenage SG1 2FX, UK.
  • Moffat JG; Department of Biochemical and Cellular Pharmacology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Zhu H; Department of Neuroscience, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Estrada AA; Department of Discovery Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Bioorg Med Chem Lett ; 29(4): 674-680, 2019 02 15.
Article en En | MEDLINE | ID: mdl-30522953
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteína 2 Quinasa Serina-Treonina Rica en Repeticiones de Leucina / Indazoles Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2019 Tipo del documento: Article
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteína 2 Quinasa Serina-Treonina Rica en Repeticiones de Leucina / Indazoles Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2019 Tipo del documento: Article