RNA-seq Analysis of the SCN1A-KO Model based on CRISPR/Cas9 Genome Editing Technology.

Shi, Xiaoguang; He, Wenxin; Guo, Shanshan; Zhang, Bingying; Ren, Shuanglai; Liu, Kunmei; Sun, Tao; Cui, Jianqi

Shi, Xiaoguang; He, Wenxin; Guo, Shanshan; Zhang, Bingying; Ren, Shuanglai; Liu, Kunmei; Sun, Tao; Cui, Jianqi.

Afiliación

Shi X; The Ningxia Key Laboratory of Cerebrocranial Diseases, Incubation Base of the National Key Laboratory, Ningxia Medical University, Yinchuan, China.
He W; The Ningxia Key Laboratory of Cerebrocranial Diseases, Incubation Base of the National Key Laboratory, Ningxia Medical University, Yinchuan, China.
Guo S; The Ningxia Key Laboratory of Cerebrocranial Diseases, Incubation Base of the National Key Laboratory, Ningxia Medical University, Yinchuan, China.
Zhang B; Department of Biochemistry and Molecular Biology, The School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, China.
Ren S; The Ningxia Key Laboratory of Cerebrocranial Diseases, Incubation Base of the National Key Laboratory, Ningxia Medical University, Yinchuan, China.
Liu K; The Ningxia Key Laboratory of Cerebrocranial Diseases, Incubation Base of the National Key Laboratory, Ningxia Medical University, Yinchuan, China.
Sun T; The Ningxia Key Laboratory of Cerebrocranial Diseases, Incubation Base of the National Key Laboratory, Ningxia Medical University, Yinchuan, China.
Cui J; The Ningxia Key Laboratory of Cerebrocranial Diseases, Incubation Base of the National Key Laboratory, Ningxia Medical University, Yinchuan, China; Department of Biochemistry and Molecular Biology, The School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, China. Electronic address:

Neuroscience ; 398: 1-11, 2019 02 01.

Article en En | MEDLINE | ID: mdl-30529264

Asunto(s)

Sistemas CRISPR-Cas; Edición Génica; Técnicas de Inactivación de Genes; Canal de Sodio Activado por Voltaje NAV1.1/deficiencia; Animales; Línea Celular; Epilepsias Mioclónicas/genética; Epilepsias Mioclónicas/metabolismo; Expresión Génica; Técnicas de Inactivación de Genes/métodos; Ratones; Canal de Sodio Activado por Voltaje NAV1.1/genética; ARN Mensajero/metabolismo; Análisis de Secuencia de ARN; Transducción de Señal

Palabras clave

CRISPR/Cas9; Dravet syndrome; RNA-seq; SCN1A; epilepsy; genomics

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Técnicas de Inactivación de Genes / Canal de Sodio Activado por Voltaje NAV1.1 / Sistemas CRISPR-Cas / Edición Génica Límite: Animals Idioma: En Revista: Neuroscience Año: 2019 Tipo del documento: Article País de afiliación: China

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