Antiviral effects of selected nucleoside analogues against human parechoviruses A1 and A3.
Antiviral Res
; 162: 51-53, 2019 02.
Article
en En
| MEDLINE
| ID: mdl-30550798
ABSTRACT
Parechoviruses A (HPeV, Picornaviridae) are neglected human pathogens that cause sepsis-like illness and severe neurological complications in infants. There are no antivirals available for the treatment of HPeV infections. We here report on cell-based assays that allow for medium-throughput antiviral screening of compound libraries against HPeV. The nucleoside viral polymerase inhibitor 2'-C-methylcytidine was identified as being an in vitro replication inhibitor of HPeV1 and HPeV3 that can serve as a reference molecule for further antiviral studies.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Antivirales
/
Parechovirus
/
Nucleósidos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Antiviral Res
Año:
2019
Tipo del documento:
Article
País de afiliación:
Bélgica