Lrrk promotes tau neurotoxicity through dysregulation of actin and mitochondrial dynamics.

Bardai, Farah H; Ordonez, Dalila G; Bailey, Rachel M; Hamm, Matthew; Lewis, Jada; Feany, Mel B

Bardai, Farah H; Ordonez, Dalila G; Bailey, Rachel M; Hamm, Matthew; Lewis, Jada; Feany, Mel B.

Afiliación

Bardai FH; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.
Ordonez DG; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.
Bailey RM; Department of Neuroscience and Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, Florida, United States of America.
Hamm M; Department of Neuroscience and Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, Florida, United States of America.
Lewis J; Department of Neuroscience and Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, Florida, United States of America.
Feany MB; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.

PLoS Biol ; 16(12): e2006265, 2018 12.

Article en En | MEDLINE | ID: mdl-30571694

Asunto(s)

Proteína 2 Quinasa Serina-Treonina Rica en Repeticiones de Leucina/metabolismo; Proteína 2 Quinasa Serina-Treonina Rica en Repeticiones de Leucina/fisiología; Tauopatías/metabolismo; Citoesqueleto de Actina/metabolismo; Actinas/metabolismo; Animales; Modelos Animales de Enfermedad; Proteínas de Drosophila/genética; Proteínas de Drosophila/fisiología; Drosophila melanogaster/metabolismo; Humanos; Proteína 2 Quinasa Serina-Treonina Rica en Repeticiones de Leucina/genética; Ratones; Ratones Transgénicos; Dinámicas Mitocondriales/fisiología; Mutación; Neuronas/metabolismo; Enfermedad de Parkinson/genética; Unión Proteica; Proteínas Serina-Treonina Quinasas/genética; Proteínas Serina-Treonina Quinasas/metabolismo; Proteínas Serina-Treonina Quinasas/fisiología; Proteínas tau/metabolismo

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Tauopatías / Proteína 2 Quinasa Serina-Treonina Rica en Repeticiones de Leucina Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: PLoS Biol Asunto de la revista: BIOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google