The Solution Structure of FUS Bound to RNA Reveals a Bipartite Mode of RNA Recognition with Both Sequence and Shape Specificity.

Loughlin, Fionna E; Lukavsky, Peter J; Kazeeva, Tamara; Reber, Stefan; Hock, Eva-Maria; Colombo, Martino; Von Schroetter, Christine; Pauli, Phillip; Cléry, Antoine; Mühlemann, Oliver; Polymenidou, Magdalini; Ruepp, Marc-David; Allain, Frédéric H-T

Loughlin, Fionna E; Lukavsky, Peter J; Kazeeva, Tamara; Reber, Stefan; Hock, Eva-Maria; Colombo, Martino; Von Schroetter, Christine; Pauli, Phillip; Cléry, Antoine; Mühlemann, Oliver; Polymenidou, Magdalini; Ruepp, Marc-David; Allain, Frédéric H-T.

Afiliación

Loughlin FE; Department of Biology, Institute of Molecular Biology and Biophysics, ETH Zürich, 8093 Zürich, Switzerland; Monash Biomedicine Discovery Institute, Department of Biochemistry and Molecular Biology, Monash University, Clayton, 3800 VIC, Australia. Electronic address: fionna.loughlin@monash.edu.
Lukavsky PJ; Department of Biology, Institute of Molecular Biology and Biophysics, ETH Zürich, 8093 Zürich, Switzerland.
Kazeeva T; Department of Biology, Institute of Molecular Biology and Biophysics, ETH Zürich, 8093 Zürich, Switzerland.
Reber S; Department of Chemistry and Biochemistry, University of Bern, 3012 Bern, Switzerland; Graduate School for Cellular and Biomedical Sciences, University of Bern, 3012 Bern, Switzerland.
Hock EM; Institute of Molecular Life Sciences, University of Zurich, 8057 Zurich, Switzerland.
Colombo M; Department of Chemistry and Biochemistry, University of Bern, 3012 Bern, Switzerland; Graduate School for Cellular and Biomedical Sciences, University of Bern, 3012 Bern, Switzerland.
Von Schroetter C; Department of Biology, Institute of Molecular Biology and Biophysics, ETH Zürich, 8093 Zürich, Switzerland.
Pauli P; Department of Biology, Institute of Molecular Biology and Biophysics, ETH Zürich, 8093 Zürich, Switzerland.
Cléry A; Department of Biology, Institute of Molecular Biology and Biophysics, ETH Zürich, 8093 Zürich, Switzerland.
Mühlemann O; Department of Chemistry and Biochemistry, University of Bern, 3012 Bern, Switzerland.
Polymenidou M; Institute of Molecular Life Sciences, University of Zurich, 8057 Zurich, Switzerland.
Ruepp MD; Department of Chemistry and Biochemistry, University of Bern, 3012 Bern, Switzerland.
Allain FH; Department of Biology, Institute of Molecular Biology and Biophysics, ETH Zürich, 8093 Zürich, Switzerland. Electronic address: allain@mol.biol.ethz.ch.

Mol Cell ; 73(3): 490-504.e6, 2019 02 07.

Article en En | MEDLINE | ID: mdl-30581145

Asunto(s)

Proteína FUS de Unión a ARN/química; ARN/química; Sitios de Unión; Células HeLa; Humanos; Modelos Moleculares; Motivos de Nucleótidos; Unión Proteica; Dominios y Motivos de Interacción de Proteínas; ARN/genética; ARN/metabolismo; Motivo de Reconocimiento de ARN; Empalme del ARN; Estabilidad del ARN; Proteína FUS de Unión a ARN/genética; Proteína FUS de Unión a ARN/metabolismo; Relación Estructura-Actividad; Dedos de Zinc

Palabras clave

Arg-Gly-Gly; RNA recognition motif; alternative-splicing; amyotrophic lateral sclerosis; frontotemporal lobar degeneration; fused in sarcoma; nuclear magnetic resonance spectroscopy; protein-RNA complex; ribonucleoprotein; zinc finger

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: ARN / Proteína FUS de Unión a ARN Límite: Humans Idioma: En Revista: Mol Cell Asunto de la revista: BIOLOGIA MOLECULAR Año: 2019 Tipo del documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google