Bichirs employ similar genetic pathways for limb regeneration as are used in lungfish and salamanders.
Gene
; 690: 68-74, 2019 Mar 30.
Article
en En
| MEDLINE
| ID: mdl-30583027
ABSTRACT
Bichirs are a sister group to sarcopterygian and tetrapods that can fully regenerate their endochondral-skeleton-fins. Histological and transcriptomic comparison approaches have been used to investigate the morphology and genetic basis of bichir lobe-fin regeneration, with strong down-regulation of muscle-related genes and up-regulation of ECM-related genes and developmental genes being observed. Bichir limb regeneration involves similar cellular processes to those employed by lungfish and salamander, with MARCKS-like protein (MLP) that is known to be a putative regeneration-initiating molecule in salamander, also up-regulated in the early stages of bichir lobe-fin regeneration. These gene expression results suggest that limb regeneration pathways in these amphibians have a common ancestral inheritance, consistent with evolution from endochondral-skeleton-fin structures to endochondral-skeleton-limb structures of vertebrates.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Urodelos
/
Perfilación de la Expresión Génica
/
Redes Reguladoras de Genes
/
Peces
Límite:
Animals
Idioma:
En
Revista:
Gene
Año:
2019
Tipo del documento:
Article