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Discovery of Tetrahydropyridopyrimidines as Irreversible Covalent Inhibitors of KRAS-G12C with In Vivo Activity.
Fell, Jay B; Fischer, John P; Baer, Brian R; Ballard, Joshua; Blake, James F; Bouhana, Karyn; Brandhuber, Barbara J; Briere, David M; Burgess, Laurence E; Burkard, Michael R; Chiang, Harrah; Chicarelli, Mark J; Davidson, Kevin; Gaudino, John J; Hallin, Jill; Hanson, Lauren; Hee, Kenneth; Hicken, Erik J; Hinklin, Ronald J; Marx, Matthew A; Mejia, Macedonio J; Olson, Peter; Savechenkov, Pavel; Sudhakar, Niranjan; Tang, Tony P; Vigers, Guy P; Zecca, Henry; Christensen, James G.
Afiliación
  • Fell JB; Array BioPharma, Inc., 3200 Walnut Street, Boulder, Colorado 80301, United States.
  • Fischer JP; Array BioPharma, Inc., 3200 Walnut Street, Boulder, Colorado 80301, United States.
  • Baer BR; Array BioPharma, Inc., 3200 Walnut Street, Boulder, Colorado 80301, United States.
  • Ballard J; Array BioPharma, Inc., 3200 Walnut Street, Boulder, Colorado 80301, United States.
  • Blake JF; Array BioPharma, Inc., 3200 Walnut Street, Boulder, Colorado 80301, United States.
  • Bouhana K; Array BioPharma, Inc., 3200 Walnut Street, Boulder, Colorado 80301, United States.
  • Brandhuber BJ; Array BioPharma, Inc., 3200 Walnut Street, Boulder, Colorado 80301, United States.
  • Briere DM; Mirati Therapeutics, Inc., 9393 Towne Centre Drive, Suite 200, San Diego, California 92121, United States.
  • Burgess LE; Array BioPharma, Inc., 3200 Walnut Street, Boulder, Colorado 80301, United States.
  • Burkard MR; Array BioPharma, Inc., 3200 Walnut Street, Boulder, Colorado 80301, United States.
  • Chiang H; Mirati Therapeutics, Inc., 9393 Towne Centre Drive, Suite 200, San Diego, California 92121, United States.
  • Chicarelli MJ; Array BioPharma, Inc., 3200 Walnut Street, Boulder, Colorado 80301, United States.
  • Davidson K; Array BioPharma, Inc., 3200 Walnut Street, Boulder, Colorado 80301, United States.
  • Gaudino JJ; Array BioPharma, Inc., 3200 Walnut Street, Boulder, Colorado 80301, United States.
  • Hallin J; Mirati Therapeutics, Inc., 9393 Towne Centre Drive, Suite 200, San Diego, California 92121, United States.
  • Hanson L; Array BioPharma, Inc., 3200 Walnut Street, Boulder, Colorado 80301, United States.
  • Hee K; Array BioPharma, Inc., 3200 Walnut Street, Boulder, Colorado 80301, United States.
  • Hicken EJ; Array BioPharma, Inc., 3200 Walnut Street, Boulder, Colorado 80301, United States.
  • Hinklin RJ; Array BioPharma, Inc., 3200 Walnut Street, Boulder, Colorado 80301, United States.
  • Marx MA; Mirati Therapeutics, Inc., 9393 Towne Centre Drive, Suite 200, San Diego, California 92121, United States.
  • Mejia MJ; Array BioPharma, Inc., 3200 Walnut Street, Boulder, Colorado 80301, United States.
  • Olson P; Mirati Therapeutics, Inc., 9393 Towne Centre Drive, Suite 200, San Diego, California 92121, United States.
  • Savechenkov P; Array BioPharma, Inc., 3200 Walnut Street, Boulder, Colorado 80301, United States.
  • Sudhakar N; Mirati Therapeutics, Inc., 9393 Towne Centre Drive, Suite 200, San Diego, California 92121, United States.
  • Tang TP; Array BioPharma, Inc., 3200 Walnut Street, Boulder, Colorado 80301, United States.
  • Vigers GP; Array BioPharma, Inc., 3200 Walnut Street, Boulder, Colorado 80301, United States.
  • Zecca H; Array BioPharma, Inc., 3200 Walnut Street, Boulder, Colorado 80301, United States.
  • Christensen JG; Mirati Therapeutics, Inc., 9393 Towne Centre Drive, Suite 200, San Diego, California 92121, United States.
ACS Med Chem Lett ; 9(12): 1230-1234, 2018 Dec 13.
Article en En | MEDLINE | ID: mdl-30613331
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: ACS Med Chem Lett Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: ACS Med Chem Lett Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos