Clinical and genetic characterization of de novo double-hit B cell precursor leukemia/lymphoma.

Stratmann, Jan A; von Rose, Aaron Becker; Koschade, Sebastian; Wendelin, Knut; Köhler, Friedemann; Heinsch, Michael; Schiller, Kilian; Haferlach, Claudia; Wattad, Mohamed; Rieder, Harald; Serve, Hubert; Gökbuget, Nicola; Steffen, Björn

Stratmann, Jan A; von Rose, Aaron Becker; Koschade, Sebastian; Wendelin, Knut; Köhler, Friedemann; Heinsch, Michael; Schiller, Kilian; Haferlach, Claudia; Wattad, Mohamed; Rieder, Harald; Serve, Hubert; Gökbuget, Nicola; Steffen, Björn.

Afiliación

Stratmann JA; Department of Hematology and Oncology, Johann Wolfgang Goethe University of Frankfurt, Theodor Stern Kai 7, 60596, Frankfurt am Main, Germany. jan.stratmann@kgu.de.
von Rose AB; Department of Hematology and Oncology, Johann Wolfgang Goethe University of Frankfurt, Theodor Stern Kai 7, 60596, Frankfurt am Main, Germany.
Koschade S; Department of Hematology and Oncology, Johann Wolfgang Goethe University of Frankfurt, Theodor Stern Kai 7, 60596, Frankfurt am Main, Germany.
Wendelin K; Department of Hematology and Medical Oncology, Paracelsus Medical University, Prof.-Ernst-Nathan-Str. 1, 90419, Nuremberg, Germany.
Köhler F; Department of. Internal Medicine II, Schwarzwald-Baar Clinic Villingen-Schwenningen, Klinikstr. 11, 78052, Villingen-Schwenningen, Germany.
Heinsch M; Department of Internal Medicine II, St Johannes Hospital, An der Abtei 7-11, 47166, Duisburg, Germany.
Schiller K; Department of Radiation Oncology, Technical University of Munich (TUM), Ismaninger Strasse 22, 81675, Munich, Germany.
Haferlach C; Munich Leukemia Laboratory (MLL), Max-Lebsche-Platz 31, 81377, Munich, Germany.
Wattad M; Department of Hematology and Oncology, Hospital Essen-Werden, Pattbergstraße 1-3, 45239, Essen, Germany.
Rieder H; Institute for Human Genetics, Medical Faculty, Heinrich-Heine-University, Moorenstraße 5, 40225, Düsseldorf, Germany.
Serve H; Department of Hematology and Oncology, Johann Wolfgang Goethe University of Frankfurt, Theodor Stern Kai 7, 60596, Frankfurt am Main, Germany.
Gökbuget N; Department of Hematology and Oncology, Johann Wolfgang Goethe University of Frankfurt, Theodor Stern Kai 7, 60596, Frankfurt am Main, Germany.
Steffen B; Department of Hematology and Oncology, Johann Wolfgang Goethe University of Frankfurt, Theodor Stern Kai 7, 60596, Frankfurt am Main, Germany.

Ann Hematol ; 98(3): 647-656, 2019 Mar.

Article en En | MEDLINE | ID: mdl-30613837

Asunto(s)

Genes bcl-2; Genes myc; Leucemia-Linfoma Linfoblástico de Células Precursoras/clasificación; Proteínas Proto-Oncogénicas c-bcl-6/genética; Adolescente; Adulto; Anciano; Anciano de 80 o más Años; Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico; Femenino; Reordenamiento Génico de Linfocito B; Humanos; Infiltración Leucémica; Masculino; Persona de Mediana Edad; Leucemia-Linfoma Linfoblástico de Células Precursoras/epidemiología; Leucemia-Linfoma Linfoblástico de Células Precursoras/genética; Leucemia-Linfoma Linfoblástico de Células Precursoras/patología; Pronóstico; Supervivencia sin Progresión; Recurrencia; Terapia Recuperativa; Translocación Genética; Adulto Joven

Palabras clave

Acute lymphoblastic B cell precursor leukemia; BCL2; Double-hit; Extramedullary manifestation; MYC; Salvage treatment

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Genes myc / Genes bcl-2 / Proteínas Proto-Oncogénicas c-bcl-6 / Leucemia-Linfoma Linfoblástico de Células Precursoras Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Hematol Asunto de la revista: HEMATOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Alemania

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